FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022187101> ?p ?o ?g. }

• W2022187101 endingPage "2830" @default.
• W2022187101 startingPage "2823" @default.
• W2022187101 abstract "Endocrine regulation of tissue glucose-6-phosphatase activity in utero was examined by measuring enzyme levels in liver and kidneys of fetal sheep during the second half of gestation and after experimental manipulation of fetal plasma cortisol and insulin levels. Tissue glucose-6-phosphatase activities increased toward term in parallel with the rise in fetal plasma cortisol. At birth, the activities were significantly higher than in utero, but significantly less than in adult nonpregnant sheep. Fetal hypophysectomy lowered fetal plasma cortisol and reduced hepatic and renal glucose-6-phosphatase activities compared with those in intact fetuses near term. Conversely, intrafetal cortisol infusion raised fetal plasma cortisol and significantly increased tissue glucose-6-phosphatase activity to values similar to those in older fetuses. When the data from these groups of fetuses and the newborn lambs were combined, there was a significant positive correlation between the plasma cortisol level and the glucose-6-phosphatase activity in both liver and kidney. Fetal hypoinsulinemia was induced by fasting the ewe for 48 h and by fetal pancreatectomy. Fetal hepatic and renal glucose-6-phosphatase activities were higher in fasted than in fed animals, while pancreatectomy had little apparent effect on enzyme activity in either tissue. However, when differences in plasma cortisol were taken into account, hepatic, but not renal, glucose-6-phosphatase activities were higher in both groups of hypoinsulinemic fetuses than would have been observed in normoinsulinemic animals with a similar plasma cortisol level. Partial correlation analysis of the data showed that plasma insulin and cortisol were both significant influences on hepatic glucose-6-phosphatase activity in utero, but plasma cortisol had the more pronounced effect. Cortisol, therefore, appears to be a physiological regulator of tissue glucose-6-phosphatase activity in utero and enhances the glucogenic capacity of the sheep fetus during late gestation. (Endocrinology126: 2823–2830, 1990)" @default.
• W2022187101 created "2016-06-24" @default.
• W2022187101 creator A5050299817 @default.
• W2022187101 creator A5076033951 @default.
• W2022187101 creator A5087767619 @default.
• W2022187101 date "1990-06-01" @default.
• W2022187101 modified "2023-10-12" @default.
• W2022187101 title "Endocrine Regulation of Tissue Glucose-6-Phosphatase Activity in the Fetal Sheep during Late Gestation*" @default.
• W2022187101 cites W1496459044 @default.
• W2022187101 cites W1903394488 @default.
• W2022187101 cites W1907672745 @default.
• W2022187101 cites W1969963944 @default.
• W2022187101 cites W1973759202 @default.
• W2022187101 cites W1974599197 @default.
• W2022187101 cites W1984794199 @default.
• W2022187101 cites W2006589183 @default.
• W2022187101 cites W2054180839 @default.
• W2022187101 cites W2057149022 @default.
• W2022187101 cites W2057830687 @default.
• W2022187101 cites W2062069463 @default.
• W2022187101 cites W2066124485 @default.
• W2022187101 cites W2067705409 @default.
• W2022187101 cites W2079028615 @default.
• W2022187101 cites W2080625799 @default.
• W2022187101 cites W2087276272 @default.
• W2022187101 cites W2165548216 @default.
• W2022187101 cites W2404260155 @default.
• W2022187101 cites W2407225059 @default.
• W2022187101 cites W2414116066 @default.
• W2022187101 cites W2427552101 @default.
• W2022187101 cites W2428769196 @default.
• W2022187101 cites W2467874387 @default.
• W2022187101 cites W2798643531 @default.
• W2022187101 cites W79964443 @default.
• W2022187101 doi "https://doi.org/10.1210/endo-126-6-2823" @default.
• W2022187101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2161735" @default.
• W2022187101 hasPublicationYear "1990" @default.
• W2022187101 type Work @default.
• W2022187101 sameAs 2022187101 @default.
• W2022187101 citedByCount "23" @default.
• W2022187101 countsByYear W20221871012012 @default.
• W2022187101 countsByYear W20221871012015 @default.
• W2022187101 crossrefType "journal-article" @default.
• W2022187101 hasAuthorship W2022187101A5050299817 @default.
• W2022187101 hasAuthorship W2022187101A5076033951 @default.
• W2022187101 hasAuthorship W2022187101A5087767619 @default.
• W2022187101 hasConcept C126322002 @default.
• W2022187101 hasConcept C134018914 @default.
• W2022187101 hasConcept C160160445 @default.
• W2022187101 hasConcept C172680121 @default.
• W2022187101 hasConcept C181199279 @default.
• W2022187101 hasConcept C201614185 @default.
• W2022187101 hasConcept C2779202576 @default.
• W2022187101 hasConcept C2779234561 @default.
• W2022187101 hasConcept C2779306644 @default.
• W2022187101 hasConcept C2780091579 @default.
• W2022187101 hasConcept C46973012 @default.
• W2022187101 hasConcept C54355233 @default.
• W2022187101 hasConcept C55493867 @default.
• W2022187101 hasConcept C71924100 @default.
• W2022187101 hasConcept C86803240 @default.
• W2022187101 hasConceptScore W2022187101C126322002 @default.
• W2022187101 hasConceptScore W2022187101C134018914 @default.
• W2022187101 hasConceptScore W2022187101C160160445 @default.
• W2022187101 hasConceptScore W2022187101C172680121 @default.
• W2022187101 hasConceptScore W2022187101C181199279 @default.
• W2022187101 hasConceptScore W2022187101C201614185 @default.
• W2022187101 hasConceptScore W2022187101C2779202576 @default.
• W2022187101 hasConceptScore W2022187101C2779234561 @default.
• W2022187101 hasConceptScore W2022187101C2779306644 @default.
• W2022187101 hasConceptScore W2022187101C2780091579 @default.
• W2022187101 hasConceptScore W2022187101C46973012 @default.
• W2022187101 hasConceptScore W2022187101C54355233 @default.
• W2022187101 hasConceptScore W2022187101C55493867 @default.
• W2022187101 hasConceptScore W2022187101C71924100 @default.
• W2022187101 hasConceptScore W2022187101C86803240 @default.
• W2022187101 hasIssue "6" @default.
• W2022187101 hasLocation W20221871011 @default.
• W2022187101 hasLocation W20221871012 @default.
• W2022187101 hasOpenAccess W2022187101 @default.
• W2022187101 hasPrimaryLocation W20221871011 @default.
• W2022187101 hasRelatedWork W1996912214 @default.
• W2022187101 hasRelatedWork W2004317605 @default.
• W2022187101 hasRelatedWork W2034531855 @default.
• W2022187101 hasRelatedWork W2041269450 @default.
• W2022187101 hasRelatedWork W2046375634 @default.
• W2022187101 hasRelatedWork W2063828562 @default.
• W2022187101 hasRelatedWork W2107304850 @default.
• W2022187101 hasRelatedWork W2376074409 @default.
• W2022187101 hasRelatedWork W2379908895 @default.
• W2022187101 hasRelatedWork W2397830406 @default.
• W2022187101 hasVolume "126" @default.
• W2022187101 isParatext "false" @default.
• W2022187101 isRetracted "false" @default.
• W2022187101 magId "2022187101" @default.
• W2022187101 workType "article" @default.