FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022187555> ?p ?o ?g. }

• W2022187555 endingPage "190" @default.
• W2022187555 startingPage "186" @default.
• W2022187555 abstract "Activation of phospholipase Cβ (PLCβ) by G proteins leads to a chain of events that result in an increase in intracellular calcium and activation of protein kinase C (PKC). It has been found that PKC phosphorylates PLCβ1 on S887 in vitro without affecting its enzymatic activity or its ability to be activated by Gα(q) proteins. To understand whether S887 phosphorylation affects the enzyme’s activity in cells, we constructed two mutants that mimic the wild type and PKC-phosphorylated enzymes (S887A and S887D). We find that these constructs bind similarly to Gα(q) in vitro. When expressed in HEK293 cells, both mutants associate identically to Gα(q) in both the basal and stimulated states. Both mutants diffuse with similar rates and also interact identically with another known binding partner, translin-associated factor X (TRAX), which associates with PLCβ1 in the cytosol and nucleus. However, the two mutants localize differently in the cell. We find that S887A has a much higher nuclear localization than its S887D counterpart both in HEK293 cells and PC12 cells. Our studies suggest that PKC phosphorylation regulates the level of PLCβ1 cytosolic and nuclear activity by regulating its cellular compartmentalization." @default.
• W2022187555 created "2016-06-24" @default.
• W2022187555 creator A5020122874 @default.
• W2022187555 creator A5022668392 @default.
• W2022187555 creator A5032136628 @default.
• W2022187555 date "2011-05-01" @default.
• W2022187555 modified "2023-09-23" @default.
• W2022187555 title "Protein kinase C phosphorylation of PLCβ1 regulates its cellular localization" @default.
• W2022187555 cites W148785554 @default.
• W2022187555 cites W1549843892 @default.
• W2022187555 cites W1585941903 @default.
• W2022187555 cites W1793395791 @default.
• W2022187555 cites W1965262675 @default.
• W2022187555 cites W2005644977 @default.
• W2022187555 cites W2015226319 @default.
• W2022187555 cites W2026494112 @default.
• W2022187555 cites W2034983225 @default.
• W2022187555 cites W2053869689 @default.
• W2022187555 cites W2054755210 @default.
• W2022187555 cites W2067861784 @default.
• W2022187555 cites W2076201880 @default.
• W2022187555 cites W2088085878 @default.
• W2022187555 cites W2095367518 @default.
• W2022187555 cites W2096549360 @default.
• W2022187555 cites W2109694440 @default.
• W2022187555 cites W2121808401 @default.
• W2022187555 cites W2149732267 @default.
• W2022187555 cites W2154298653 @default.
• W2022187555 cites W2416727200 @default.
• W2022187555 cites W2425190918 @default.
• W2022187555 doi "https://doi.org/10.1016/j.abb.2011.02.006" @default.
• W2022187555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3081424" @default.
• W2022187555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21338571" @default.
• W2022187555 hasPublicationYear "2011" @default.
• W2022187555 type Work @default.
• W2022187555 sameAs 2022187555 @default.
• W2022187555 citedByCount "27" @default.
• W2022187555 countsByYear W20221875552012 @default.
• W2022187555 countsByYear W20221875552013 @default.
• W2022187555 countsByYear W20221875552014 @default.
• W2022187555 countsByYear W20221875552015 @default.
• W2022187555 countsByYear W20221875552016 @default.
• W2022187555 countsByYear W20221875552017 @default.
• W2022187555 countsByYear W20221875552019 @default.
• W2022187555 countsByYear W20221875552020 @default.
• W2022187555 countsByYear W20221875552021 @default.
• W2022187555 countsByYear W20221875552022 @default.
• W2022187555 crossrefType "journal-article" @default.
• W2022187555 hasAuthorship W2022187555A5020122874 @default.
• W2022187555 hasAuthorship W2022187555A5022668392 @default.
• W2022187555 hasAuthorship W2022187555A5032136628 @default.
• W2022187555 hasBestOaLocation W20221875552 @default.
• W2022187555 hasConcept C104317684 @default.
• W2022187555 hasConcept C110455231 @default.
• W2022187555 hasConcept C11960822 @default.
• W2022187555 hasConcept C143065580 @default.
• W2022187555 hasConcept C153911025 @default.
• W2022187555 hasConcept C174510640 @default.
• W2022187555 hasConcept C181199279 @default.
• W2022187555 hasConcept C184235292 @default.
• W2022187555 hasConcept C195794163 @default.
• W2022187555 hasConcept C2778597717 @default.
• W2022187555 hasConcept C2780723820 @default.
• W2022187555 hasConcept C49805395 @default.
• W2022187555 hasConcept C55493867 @default.
• W2022187555 hasConcept C62478195 @default.
• W2022187555 hasConcept C66135807 @default.
• W2022187555 hasConcept C79879829 @default.
• W2022187555 hasConcept C80631254 @default.
• W2022187555 hasConcept C86803240 @default.
• W2022187555 hasConcept C95444343 @default.
• W2022187555 hasConcept C97029542 @default.
• W2022187555 hasConcept C98539663 @default.
• W2022187555 hasConceptScore W2022187555C104317684 @default.
• W2022187555 hasConceptScore W2022187555C110455231 @default.
• W2022187555 hasConceptScore W2022187555C11960822 @default.
• W2022187555 hasConceptScore W2022187555C143065580 @default.
• W2022187555 hasConceptScore W2022187555C153911025 @default.
• W2022187555 hasConceptScore W2022187555C174510640 @default.
• W2022187555 hasConceptScore W2022187555C181199279 @default.
• W2022187555 hasConceptScore W2022187555C184235292 @default.
• W2022187555 hasConceptScore W2022187555C195794163 @default.
• W2022187555 hasConceptScore W2022187555C2778597717 @default.
• W2022187555 hasConceptScore W2022187555C2780723820 @default.
• W2022187555 hasConceptScore W2022187555C49805395 @default.
• W2022187555 hasConceptScore W2022187555C55493867 @default.
• W2022187555 hasConceptScore W2022187555C62478195 @default.
• W2022187555 hasConceptScore W2022187555C66135807 @default.
• W2022187555 hasConceptScore W2022187555C79879829 @default.
• W2022187555 hasConceptScore W2022187555C80631254 @default.
• W2022187555 hasConceptScore W2022187555C86803240 @default.
• W2022187555 hasConceptScore W2022187555C95444343 @default.
• W2022187555 hasConceptScore W2022187555C97029542 @default.
• W2022187555 hasConceptScore W2022187555C98539663 @default.
• W2022187555 hasIssue "2" @default.
• W2022187555 hasLocation W20221875551 @default.
• W2022187555 hasLocation W20221875552 @default.
• W2022187555 hasLocation W20221875553 @default.

• next