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- W2022187963 abstract "The hypothesis of a stimulatory effect of aldosterone on RNA, and consequently protein synthesis has been investigated. The influence of this hormone on the incorporation of precursors into RNA and protein was examined in the toad urinary bladder through which sodium transport is stimulated by aldosterone in vitro.Aldosterone increases total nuclear RNA synthesis and also uridine uptake. Particular fractions of this RNA characterized by density gradient centrifugation might be specifically influenced. No effect of aldosterone on cytoplasmic RNA turn-over rate or on mRNA synthesis could be demonstrated. Examination of the pattern of protein synthesis at the polysome level, of ribosome processing, and of protein turn-over rate also failed to disclose any definite influence of aldosterone on these parameters.The proposal that the effect of aldosterone on sodium transport is mediated by its action on transcription and translation in target tissues remains therefore founded on indirect evidence to date." @default.
- W2022187963 created "2016-06-24" @default.
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- W2022187963 date "1972-02-01" @default.
- W2022187963 modified "2023-09-25" @default.
- W2022187963 title "Effects of Aldosterone on RNA and Protein Synthesis in the Toad Bladder" @default.
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- W2022187963 doi "https://doi.org/10.1111/j.1432-1033.1972.tb01727.x" @default.
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