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• W2022188895 startingPage "121" @default.
• W2022188895 abstract "Tumor necrosis factor (TNF)-α, a pleiotropic cytokine that exerts a variety of effects, such as growth promotion, growth inhibition, angiogenesis, cytotoxicity, inflammation, and immunomodulation, has been implicated in several inflammatory conditions. It plays a significant role in many inflammatory diseases of lungs. Given that there is significant literature supporting the pathobiologic role of TNF-α in asthma, mainly in severe refractory asthma, and COPD, TNF-α inhibitors (infliximab, golimumab and etanercept) are now regarded as the potential new medications in asthma and COPD management. The studies reported in literature indicate that TNF-α inhibitors are effective in a relatively small subgroup of patients with severe asthma, possibly defined by an increased TNF axis, but they seem to be ineffective in COPD, although an observational study demonstrated that TNF-α inhibitors were associated with a reduction in the rate of COPD hospitalisation among patients with COPD receiving these agents to treat their rheumatoid arthritis. These findings require a smart approach because there is still good reason to target TNF-α, perhaps in a more carefully selected patient group. TNF-α treatment should, therefore, not be thrown out, or abandoned. Indeed, since severe asthma and COPD are heterogeneous diseases that have characteristics that occur with different phenotypes that remained poorly characterized and little known about the underlying pathobiology contributing to them, it is likely that definition of these phenotypes and choice of the right outcome measure will allow us to understand which kind of patients can benefit from TNF-α inhibitors." @default.
• W2022188895 created "2016-06-24" @default.
• W2022188895 creator A5050589916 @default.
• W2022188895 creator A5060089859 @default.
• W2022188895 creator A5062907116 @default.
• W2022188895 date "2010-04-01" @default.
• W2022188895 modified "2023-09-26" @default.
• W2022188895 title "TNF-α inhibitors in asthma and COPD: We must not throw the baby out with the bath water" @default.
• W2022188895 cites W1557037837 @default.
• W2022188895 cites W1604408465 @default.
• W2022188895 cites W1636221253 @default.
• W2022188895 cites W18181778 @default.
• W2022188895 cites W1902360293 @default.
• W2022188895 cites W1965657038 @default.
• W2022188895 cites W1967777975 @default.
• W2022188895 cites W1968117332 @default.
• W2022188895 cites W1968427910 @default.
• W2022188895 cites W1968641886 @default.
• W2022188895 cites W1972940706 @default.
• W2022188895 cites W1973155194 @default.
• W2022188895 cites W1975847098 @default.
• W2022188895 cites W1977225705 @default.
• W2022188895 cites W1980638060 @default.
• W2022188895 cites W1981428780 @default.
• W2022188895 cites W1990674750 @default.
• W2022188895 cites W1991312386 @default.
• W2022188895 cites W1995177703 @default.
• W2022188895 cites W1996136023 @default.
• W2022188895 cites W1997106678 @default.
• W2022188895 cites W2007306221 @default.
• W2022188895 cites W2009703010 @default.
• W2022188895 cites W2016851538 @default.
• W2022188895 cites W2017013436 @default.
• W2022188895 cites W2017248564 @default.
• W2022188895 cites W2018619789 @default.
• W2022188895 cites W2024296219 @default.
• W2022188895 cites W2025111901 @default.
• W2022188895 cites W2026483460 @default.
• W2022188895 cites W2027998544 @default.
• W2022188895 cites W2032064406 @default.
• W2022188895 cites W2033272889 @default.
• W2022188895 cites W2035632341 @default.
• W2022188895 cites W2038595075 @default.
• W2022188895 cites W2038852940 @default.
• W2022188895 cites W2039270725 @default.
• W2022188895 cites W2041912691 @default.
• W2022188895 cites W2045789990 @default.
• W2022188895 cites W2047028405 @default.
• W2022188895 cites W2048657818 @default.
• W2022188895 cites W2050052944 @default.
• W2022188895 cites W2052739314 @default.
• W2022188895 cites W2052863900 @default.
• W2022188895 cites W2053517795 @default.
• W2022188895 cites W2053889157 @default.
• W2022188895 cites W2054829155 @default.
• W2022188895 cites W2057199361 @default.
• W2022188895 cites W2059646444 @default.
• W2022188895 cites W2061193280 @default.
• W2022188895 cites W2062177413 @default.
• W2022188895 cites W2062784484 @default.
• W2022188895 cites W2065487751 @default.
• W2022188895 cites W2065771658 @default.
• W2022188895 cites W2068103783 @default.
• W2022188895 cites W2069079702 @default.
• W2022188895 cites W2069681479 @default.
• W2022188895 cites W2071140414 @default.
• W2022188895 cites W2072738451 @default.
• W2022188895 cites W2074067866 @default.
• W2022188895 cites W2078940276 @default.
• W2022188895 cites W2079242927 @default.
• W2022188895 cites W2081833623 @default.
• W2022188895 cites W2082150979 @default.
• W2022188895 cites W2084035953 @default.
• W2022188895 cites W2084397540 @default.
• W2022188895 cites W2086860754 @default.
• W2022188895 cites W2089617845 @default.
• W2022188895 cites W2094835614 @default.
• W2022188895 cites W2101715763 @default.
• W2022188895 cites W2102996167 @default.
• W2022188895 cites W2103371739 @default.
• W2022188895 cites W2103969062 @default.
• W2022188895 cites W2104861385 @default.
• W2022188895 cites W2112334048 @default.
• W2022188895 cites W2113632571 @default.
• W2022188895 cites W2116521851 @default.
• W2022188895 cites W2116725410 @default.
• W2022188895 cites W2117207917 @default.
• W2022188895 cites W2117550937 @default.
• W2022188895 cites W2118680275 @default.
• W2022188895 cites W2120745761 @default.
• W2022188895 cites W2122666166 @default.
• W2022188895 cites W2123806340 @default.
• W2022188895 cites W2124657474 @default.
• W2022188895 cites W2130349041 @default.
• W2022188895 cites W2131882149 @default.
• W2022188895 cites W2132251075 @default.
• W2022188895 cites W2132632764 @default.
• W2022188895 cites W2136718097 @default.

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