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• W2022189167 endingPage "247" @default.
• W2022189167 startingPage "239" @default.
• W2022189167 abstract "Transforming growth factor-beta (TGF-beta) is a multifunctional regulatory peptide that can inhibit or promote the proliferation of cultured vascular smooth muscle cells (SMCs), depending on cell density (Majack, R. A. 1987. J. Cell Biol. 105:465-471). In this study, we have examined the mechanisms underlying the growth-promoting effects of TGF-beta in confluent SMC cultures. In mitogenesis assays using confluent cells, TGF-beta was found to potentiate the stimulatory effects of serum, PDGF, and basic fibroblast growth factor (bFGF), and was shown to act individually as a mitogen for SMC. In gene and protein expression experiments, TGF-beta was found to regulate the expression of PDGF-A and thrombospondin, two potential mediators of SMC proliferative events. The induction of thrombospondin protein and mRNA was density-dependent, delayed relative to its induction by PDGF and, based on cycloheximide experiments, appeared to depend on the de novo synthesis of an intermediary protein (probably PDGF-A). The relationship between PDGF-A expression and TGF-beta-mediated mitogenesis was investigated, and it was determined that a PDGF-like activity (probably PDGF-A) was the biological mediator of the growth-stimulatory effects of TGF-beta on confluent SMC. The effects of purified homodimers of PDGF-A on SMC replication were investigated, and it was determined that PDGF-AA was mitogenic for cultured SMC, particularly when used in combination with other growth factors such as bFGF and PDGF-BB. The data suggest several molecular mechanisms that may account for the ability of TGF-beta to promote the growth of confluent SMC in culture." @default.
• W2022189167 created "2016-06-24" @default.
• W2022189167 creator A5033878042 @default.
• W2022189167 creator A5071884880 @default.
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• W2022189167 date "1990-07-01" @default.
• W2022189167 modified "2023-10-18" @default.
• W2022189167 title "Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming growth factor-beta." @default.
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• W2022189167 doi "https://doi.org/10.1083/jcb.111.1.239" @default.
• W2022189167 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2116160" @default.
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