FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022189844> ?p ?o ?g. }

• W2022189844 endingPage "18" @default.
• W2022189844 startingPage "1" @default.
• W2022189844 abstract "Cells of the immune system are highly sensitive to altered gravity, and the monocyte as well as the macrophage function is proven to be impaired under microgravity conditions. In our study, we investigated the surface expression of ICAM-1 protein and expression of ICAM-1 mRNA in cells of the monocyte/macrophage system in microgravity during clinostat, parabolic flight, sounding rocket, and orbital experiments. In murine BV-2 microglial cells, we detected a downregulation of ICAM-1 expression in clinorotation experiments and a rapid and reversible downregulation in the microgravity phase of parabolic flight experiments. In contrast, ICAM-1 expression increased in macrophage-like differentiated human U937 cells during the microgravity phase of parabolic flights and in long-term microgravity provided by a 2D clinostat or during the orbital SIMBOX/Shenzhou-8 mission. In nondifferentiated U937 cells, no effect of microgravity on ICAM-1 expression could be observed during parabolic flight experiments. We conclude that disturbed immune function in microgravity could be a consequence of ICAM-1 modulation in the monocyte/macrophage system, which in turn could have a strong impact on the interaction with T lymphocytes and cell migration. Thus, ICAM-1 can be considered as a rapid-reacting and sustained gravity-regulated molecule in mammalian cells." @default.
• W2022189844 created "2016-06-24" @default.
• W2022189844 creator A5015123153 @default.
• W2022189844 creator A5015914631 @default.
• W2022189844 creator A5020114041 @default.
• W2022189844 creator A5021116683 @default.
• W2022189844 creator A5025639714 @default.
• W2022189844 creator A5030526585 @default.
• W2022189844 creator A5035642184 @default.
• W2022189844 creator A5044580723 @default.
• W2022189844 creator A5048272620 @default.
• W2022189844 creator A5049197708 @default.
• W2022189844 creator A5054626368 @default.
• W2022189844 creator A5055685628 @default.
• W2022189844 creator A5057830156 @default.
• W2022189844 creator A5061675910 @default.
• W2022189844 creator A5062594975 @default.
• W2022189844 creator A5062884157 @default.
• W2022189844 creator A5065000252 @default.
• W2022189844 creator A5067655952 @default.
• W2022189844 creator A5067948148 @default.
• W2022189844 creator A5068997745 @default.
• W2022189844 creator A5069835329 @default.
• W2022189844 creator A5075449188 @default.
• W2022189844 creator A5077525991 @default.
• W2022189844 creator A5078576501 @default.
• W2022189844 creator A5088938208 @default.
• W2022189844 creator A5091678409 @default.
• W2022189844 date "2015-01-01" @default.
• W2022189844 modified "2023-10-15" @default.
• W2022189844 title "Regulation of ICAM-1 in Cells of the Monocyte/Macrophage System in Microgravity" @default.
• W2022189844 cites W1945782775 @default.
• W2022189844 cites W1969203090 @default.
• W2022189844 cites W1973853894 @default.
• W2022189844 cites W1975377224 @default.
• W2022189844 cites W1976048853 @default.
• W2022189844 cites W1979615123 @default.
• W2022189844 cites W1988785687 @default.
• W2022189844 cites W2008581261 @default.
• W2022189844 cites W2011361113 @default.
• W2022189844 cites W2016055864 @default.
• W2022189844 cites W2025378496 @default.
• W2022189844 cites W2033048770 @default.
• W2022189844 cites W2036145275 @default.
• W2022189844 cites W2047533768 @default.
• W2022189844 cites W2049532810 @default.
• W2022189844 cites W2059248449 @default.
• W2022189844 cites W2059468320 @default.
• W2022189844 cites W2063368419 @default.
• W2022189844 cites W2068318644 @default.
• W2022189844 cites W2076211107 @default.
• W2022189844 cites W2088980710 @default.
• W2022189844 cites W2091901317 @default.
• W2022189844 cites W2096234619 @default.
• W2022189844 cites W2096292802 @default.
• W2022189844 cites W2099431779 @default.
• W2022189844 cites W2100124039 @default.
• W2022189844 cites W2112050754 @default.
• W2022189844 cites W2120862613 @default.
• W2022189844 cites W2130536825 @default.
• W2022189844 cites W2131848047 @default.
• W2022189844 cites W2132661305 @default.
• W2022189844 cites W2135077140 @default.
• W2022189844 cites W2155777849 @default.
• W2022189844 cites W2159482845 @default.
• W2022189844 cites W2168553493 @default.
• W2022189844 cites W2406276823 @default.
• W2022189844 cites W2417728353 @default.
• W2022189844 cites W2474329086 @default.
• W2022189844 cites W2993034433 @default.
• W2022189844 cites W3298286 @default.
• W2022189844 cites W4294216483 @default.
• W2022189844 cites W81129871 @default.
• W2022189844 doi "https://doi.org/10.1155/2015/538786" @default.
• W2022189844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4309248" @default.
• W2022189844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25654110" @default.
• W2022189844 hasPublicationYear "2015" @default.
• W2022189844 type Work @default.
• W2022189844 sameAs 2022189844 @default.
• W2022189844 citedByCount "48" @default.
• W2022189844 countsByYear W20221898442015 @default.
• W2022189844 countsByYear W20221898442016 @default.
• W2022189844 countsByYear W20221898442017 @default.
• W2022189844 countsByYear W20221898442018 @default.
• W2022189844 countsByYear W20221898442019 @default.
• W2022189844 countsByYear W20221898442020 @default.
• W2022189844 countsByYear W20221898442021 @default.
• W2022189844 countsByYear W20221898442022 @default.
• W2022189844 countsByYear W20221898442023 @default.
• W2022189844 crossrefType "journal-article" @default.
• W2022189844 hasAuthorship W2022189844A5015123153 @default.
• W2022189844 hasAuthorship W2022189844A5015914631 @default.
• W2022189844 hasAuthorship W2022189844A5020114041 @default.
• W2022189844 hasAuthorship W2022189844A5021116683 @default.
• W2022189844 hasAuthorship W2022189844A5025639714 @default.
• W2022189844 hasAuthorship W2022189844A5030526585 @default.
• W2022189844 hasAuthorship W2022189844A5035642184 @default.
• W2022189844 hasAuthorship W2022189844A5044580723 @default.

• next