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- W2022191515 abstract "Brain nerve growth factor (NGF) was determined in two groups of aged rats: 'good' and 'poor' performers. The animals were selected out of a population of 40 aged rats (26-28 months old) trained in a spatial learning task. Animals performing well in the test had significantly higher NGF in the hippocampus when compared to 'poor' performers. No differences in the levels of NGF were found in the cortex, septum and cerebellum. The results implicate hippocampal NGF in cognitive functioning of aged rats, and suggests that the forebrain cholinergic neuronal atrophy which has been observed in cognitively impaired aged rats may be due to reduced availability of target-derived NGF." @default.
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- W2022191515 date "1992-05-01" @default.
- W2022191515 modified "2023-10-01" @default.
- W2022191515 title "Hippocampal nerve growth factor levels are related to spatial learning ability in aged rats" @default.
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- W2022191515 doi "https://doi.org/10.1016/s0166-4328(05)80134-2" @default.
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