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- W2022192068 abstract "Purpose: Microsphere brachytherapy, also known as selective internal radiation therapy (SIRT), is a brachytherapy technique in which radiation is delivered by microspheres injected into regions of the liver intra-arterially. The radioisotope, 90Y, is either surface loaded on resin spheres (SIR-Spheres®, Sirtex Medical) or impregnated in glass spheres (Therasphere®, M.D.S. Nordion). The therapy is FDA approved for unresectable hepatocellular carcinoma and metastatic hepatic cancer. This treatment has shown promise but presently there is difficulty in demonstrating a clear relationship between administered activities and patient outcome. The minuscule gamma radiation of 90Y makes assessing the in vivo distribution of 90Y-labeled microspheres difficult and, for simplification, homogeneous distributions are typically assumed. Research on explanted livers has shown that microspheres preferentially deposit in tumors with uptake ratios ranging between 1:1 and 200:1. These ratios are not utilized when calculating tumor and liver doses, however, and can lead to the underestimation of tumor dose and overestimation of liver dose. The purpose of this research is to develop positron-emitting microspheres that will accurately assess the in vivo distribution of 90Y-labeled microspheres." @default.
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- W2022192068 date "2007-04-01" @default.
- W2022192068 modified "2023-10-17" @default.
- W2022192068 title "Positron-emitting microspheres for assessing dose distributions in liver microsphere brachytherapy" @default.
- W2022192068 doi "https://doi.org/10.1016/j.brachy.2007.02.115" @default.
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