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- W2022192305 abstract "Fimbrial (type 1, P, and S) and afimbrial adhesins, the unique virulence traits of uropathogenic Escherichia coli (UPEC), are well recognized for their role in the initial step of uropathogenesis. In this study, we investigated whether these adhesins are dispensable for UPEC in adherence and invasion of uroepithelial cells by using E. coli isolates (n=40) from cystitis patients and T-24 cells, the bladder carcinoma cell line. We found all isolates adherent to T-24 cells within 15 min of infection. In invasion assay, all isolates could invade T-24 cells to a variable degree; 22.5% of them were found highly invasive. About 33% of isolates that do not have any recognized adhesins were as invasive as other isolates. The amplitude of invasiveness was also independent of the adhesins. In conclusion, this study demonstrates that type 1 fimbriae, P fimbriae, S fimbriae, and afimbrial adhesin I are not required for UPEC to adhere to and invade uroepithelial cells." @default.
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- W2022192305 date "2002-03-01" @default.
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- W2022192305 title "Type 1, P and S fimbriae, and afimbrial adhesin I are not essential for uropathogenic<i>Escherichia coli</i>to adhere to and invade bladder epithelial cells" @default.
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- W2022192305 doi "https://doi.org/10.1111/j.1574-695x.2002.tb00567.x" @default.
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