Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022192437> ?p ?o ?g. }
- W2022192437 endingPage "e41005" @default.
- W2022192437 startingPage "e41005" @default.
- W2022192437 abstract "SHIP-1 is an inositol phosphatase predominantly expressed in hematopoietic cells. Over the ten past years, SHIP-1 has been described as an important regulator of immune functions. Here, we characterize a new inhibitory function for SHIP-1 in NOD2 signaling. NOD2 is a crucial cytoplasmic bacterial sensor that activates proinflammatory and antimicrobial responses upon bacterial invasion. We observed that SHIP-1 decreases NOD2-induced NF-κB activation in macrophages. This negative regulation relies on its interaction with XIAP. Indeed, we observed that XIAP is an essential mediator of the NOD2 signaling pathway that enables proper NF-κB activation in macrophages. Upon NOD2 activation, SHIP-1 C-terminal proline rich domain (PRD) interacts with XIAP, thereby disturbing the interaction between XIAP and RIP2 in order to decrease NF-κB signaling." @default.
- W2022192437 created "2016-06-24" @default.
- W2022192437 creator A5005687506 @default.
- W2022192437 creator A5014777472 @default.
- W2022192437 creator A5029991706 @default.
- W2022192437 creator A5064715045 @default.
- W2022192437 creator A5068756233 @default.
- W2022192437 creator A5069196803 @default.
- W2022192437 creator A5073491898 @default.
- W2022192437 creator A5073574070 @default.
- W2022192437 creator A5084181779 @default.
- W2022192437 date "2012-07-17" @default.
- W2022192437 modified "2023-10-02" @default.
- W2022192437 title "The Inositol Phosphatase SHIP-1 Inhibits NOD2-Induced NF-κB Activation by Disturbing the Interaction of XIAP with RIP2" @default.
- W2022192437 cites W1535874622 @default.
- W2022192437 cites W1642457845 @default.
- W2022192437 cites W1642847216 @default.
- W2022192437 cites W1670573097 @default.
- W2022192437 cites W1966024067 @default.
- W2022192437 cites W1966928572 @default.
- W2022192437 cites W1969796729 @default.
- W2022192437 cites W1971997730 @default.
- W2022192437 cites W1985806780 @default.
- W2022192437 cites W1993262772 @default.
- W2022192437 cites W1994803330 @default.
- W2022192437 cites W2000999642 @default.
- W2022192437 cites W2004465286 @default.
- W2022192437 cites W2011197811 @default.
- W2022192437 cites W2011870840 @default.
- W2022192437 cites W2015011627 @default.
- W2022192437 cites W2022451156 @default.
- W2022192437 cites W2036190668 @default.
- W2022192437 cites W2037678644 @default.
- W2022192437 cites W2039597975 @default.
- W2022192437 cites W2043667001 @default.
- W2022192437 cites W2045743590 @default.
- W2022192437 cites W2053667827 @default.
- W2022192437 cites W2056462157 @default.
- W2022192437 cites W2058924545 @default.
- W2022192437 cites W2097035469 @default.
- W2022192437 cites W2099873437 @default.
- W2022192437 cites W2107425729 @default.
- W2022192437 cites W2110712160 @default.
- W2022192437 cites W2110948560 @default.
- W2022192437 cites W2111058855 @default.
- W2022192437 cites W2111900042 @default.
- W2022192437 cites W2113438288 @default.
- W2022192437 cites W2113573651 @default.
- W2022192437 cites W2124343538 @default.
- W2022192437 cites W2125309974 @default.
- W2022192437 cites W2126880379 @default.
- W2022192437 cites W2134415527 @default.
- W2022192437 cites W2135100507 @default.
- W2022192437 cites W2136155663 @default.
- W2022192437 cites W2140429278 @default.
- W2022192437 cites W2149511417 @default.
- W2022192437 cites W2149650496 @default.
- W2022192437 cites W2152381946 @default.
- W2022192437 cites W2160029849 @default.
- W2022192437 cites W2160624569 @default.
- W2022192437 cites W2162057795 @default.
- W2022192437 cites W2164251428 @default.
- W2022192437 cites W2165023381 @default.
- W2022192437 cites W2168030198 @default.
- W2022192437 cites W2169205569 @default.
- W2022192437 cites W4313333705 @default.
- W2022192437 doi "https://doi.org/10.1371/journal.pone.0041005" @default.
- W2022192437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3398883" @default.
- W2022192437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22815893" @default.
- W2022192437 hasPublicationYear "2012" @default.
- W2022192437 type Work @default.
- W2022192437 sameAs 2022192437 @default.
- W2022192437 citedByCount "23" @default.
- W2022192437 countsByYear W20221924372013 @default.
- W2022192437 countsByYear W20221924372014 @default.
- W2022192437 countsByYear W20221924372015 @default.
- W2022192437 countsByYear W20221924372016 @default.
- W2022192437 countsByYear W20221924372017 @default.
- W2022192437 countsByYear W20221924372018 @default.
- W2022192437 countsByYear W20221924372019 @default.
- W2022192437 countsByYear W20221924372021 @default.
- W2022192437 countsByYear W20221924372023 @default.
- W2022192437 crossrefType "journal-article" @default.
- W2022192437 hasAuthorship W2022192437A5005687506 @default.
- W2022192437 hasAuthorship W2022192437A5014777472 @default.
- W2022192437 hasAuthorship W2022192437A5029991706 @default.
- W2022192437 hasAuthorship W2022192437A5064715045 @default.
- W2022192437 hasAuthorship W2022192437A5068756233 @default.
- W2022192437 hasAuthorship W2022192437A5069196803 @default.
- W2022192437 hasAuthorship W2022192437A5073491898 @default.
- W2022192437 hasAuthorship W2022192437A5073574070 @default.
- W2022192437 hasAuthorship W2022192437A5084181779 @default.
- W2022192437 hasBestOaLocation W20221924371 @default.
- W2022192437 hasConcept C104317684 @default.
- W2022192437 hasConcept C136449434 @default.
- W2022192437 hasConcept C164027704 @default.
- W2022192437 hasConcept C170493617 @default.
- W2022192437 hasConcept C185592680 @default.