FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022192502> ?p ?o ?g. }

• W2022192502 endingPage "40" @default.
• W2022192502 startingPage "38" @default.
• W2022192502 abstract "Recent findings indicate that platelet-derived growth factor (PDGF) plays a role in the generation of reactive oxygen species (ROS) as second messengers in smooth muscle cells (SMC). To identify the source and signal transduction pathway of ROS formation in SMC, we investigated PDGF-induced ROS formation. Stimulation of SMC with PDGF resulted in a rapid increase of ROS production. Using an inactivating antibody, we identified the increase to be dependent on p22phox, a NAD(P)H-oxidase subunit. ROS release was completely inhibited by the Gi protein inhibitor PTX as well as an antibody against Galphai1,2, however, not by antibodies against Galphai3/0, Gas, and Gbeta1beta2. The effect of PDGF on ROS production in SMC membranes could likewise be mimicked by the use of a recombinant Galphai2 subunit but not by Galphai3, Galphai0, Gas, and Gbetagamma subunits. Immunoaffinity chromatography demonstrated coupling of Galphai1,2 to the PDGF a-receptor, which, after preincubation of the SMC membranes with PDGF, was increased in the absence of GTPgammaS but decreased in the presence of GTPgammaS and prevented by PTX treatment. These data define a novel G protein-dependent mechanism by which PDGF signaling is transduced through direct coupling of the Gai1,2 subunit of the trimeric G proteins to the PDGF tyrosine kinase receptor." @default.
• W2022192502 created "2016-06-24" @default.
• W2022192502 creator A5011949302 @default.
• W2022192502 creator A5013467946 @default.
• W2022192502 creator A5017428199 @default.
• W2022192502 creator A5027399943 @default.
• W2022192502 creator A5037834137 @default.
• W2022192502 creator A5046797962 @default.
• W2022192502 creator A5047212668 @default.
• W2022192502 creator A5060834764 @default.
• W2022192502 creator A5080937883 @default.
• W2022192502 creator A5082251197 @default.
• W2022192502 date "2002-11-01" @default.
• W2022192502 modified "2023-10-14" @default.
• W2022192502 title "Platelet‐derived growth factor activates production of reactive oxygen species by NAD(P)H‐oxidase in smooth muscle cells through Gi1,2" @default.
• W2022192502 cites W1491163588 @default.
• W2022192502 cites W1504684037 @default.
• W2022192502 cites W1524258961 @default.
• W2022192502 cites W1528007063 @default.
• W2022192502 cites W1554916523 @default.
• W2022192502 cites W1589219672 @default.
• W2022192502 cites W1603388985 @default.
• W2022192502 cites W1603561532 @default.
• W2022192502 cites W1909526655 @default.
• W2022192502 cites W1978053328 @default.
• W2022192502 cites W2005510759 @default.
• W2022192502 cites W2017663156 @default.
• W2022192502 cites W2018845192 @default.
• W2022192502 cites W2020631276 @default.
• W2022192502 cites W2021985622 @default.
• W2022192502 cites W2026578973 @default.
• W2022192502 cites W2029652412 @default.
• W2022192502 cites W2041183642 @default.
• W2022192502 cites W2046028018 @default.
• W2022192502 cites W2047841570 @default.
• W2022192502 cites W2048569323 @default.
• W2022192502 cites W2048679957 @default.
• W2022192502 cites W2055094699 @default.
• W2022192502 cites W2064826147 @default.
• W2022192502 cites W2070110969 @default.
• W2022192502 cites W2072646254 @default.
• W2022192502 cites W2073659982 @default.
• W2022192502 cites W2076344522 @default.
• W2022192502 cites W2087886422 @default.
• W2022192502 cites W2101745219 @default.
• W2022192502 cites W2103687576 @default.
• W2022192502 cites W2104251051 @default.
• W2022192502 cites W2109223015 @default.
• W2022192502 cites W2110121929 @default.
• W2022192502 cites W2110182057 @default.
• W2022192502 cites W2110887378 @default.
• W2022192502 cites W2119210469 @default.
• W2022192502 cites W2129301938 @default.
• W2022192502 cites W2137570167 @default.
• W2022192502 cites W2144265390 @default.
• W2022192502 cites W2144779602 @default.
• W2022192502 cites W2150868462 @default.
• W2022192502 cites W2166662752 @default.
• W2022192502 cites W2170475600 @default.
• W2022192502 cites W2236373896 @default.
• W2022192502 cites W2337879654 @default.
• W2022192502 cites W4244698732 @default.
• W2022192502 doi "https://doi.org/10.1096/fj.01-1036fje" @default.
• W2022192502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12424219" @default.
• W2022192502 hasPublicationYear "2002" @default.
• W2022192502 type Work @default.
• W2022192502 sameAs 2022192502 @default.
• W2022192502 citedByCount "77" @default.
• W2022192502 countsByYear W20221925022012 @default.
• W2022192502 countsByYear W20221925022013 @default.
• W2022192502 countsByYear W20221925022014 @default.
• W2022192502 countsByYear W20221925022015 @default.
• W2022192502 countsByYear W20221925022016 @default.
• W2022192502 countsByYear W20221925022017 @default.
• W2022192502 countsByYear W20221925022018 @default.
• W2022192502 countsByYear W20221925022019 @default.
• W2022192502 countsByYear W20221925022020 @default.
• W2022192502 countsByYear W20221925022022 @default.
• W2022192502 crossrefType "journal-article" @default.
• W2022192502 hasAuthorship W2022192502A5011949302 @default.
• W2022192502 hasAuthorship W2022192502A5013467946 @default.
• W2022192502 hasAuthorship W2022192502A5017428199 @default.
• W2022192502 hasAuthorship W2022192502A5027399943 @default.
• W2022192502 hasAuthorship W2022192502A5037834137 @default.
• W2022192502 hasAuthorship W2022192502A5046797962 @default.
• W2022192502 hasAuthorship W2022192502A5047212668 @default.
• W2022192502 hasAuthorship W2022192502A5060834764 @default.
• W2022192502 hasAuthorship W2022192502A5080937883 @default.
• W2022192502 hasAuthorship W2022192502A5082251197 @default.
• W2022192502 hasConcept C104292427 @default.
• W2022192502 hasConcept C104317684 @default.
• W2022192502 hasConcept C153911025 @default.
• W2022192502 hasConcept C170493617 @default.
• W2022192502 hasConcept C180361614 @default.
• W2022192502 hasConcept C185592680 @default.
• W2022192502 hasConcept C2775960820 @default.
• W2022192502 hasConcept C2778684643 @default.
• W2022192502 hasConcept C2779719074 @default.

• next