Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022192565> ?p ?o ?g. }
- W2022192565 abstract "Enteroaggregative Escherichia coli (EAEC) is an important cause of acute and chronic diarrhea worldwide. It has been shown that flagellin (FliC), a major bacterial surface protein of EAEC, causes IL-8 release from certain epithelial cell lines via activation of TLR-5. Based on the ability of this protein to activate innate immunity, flagellin can be considered as a potent adjuvant in new vaccines and adjuvant effects of native or recombinant forms of flagellin have been demonstrated. In the current study we designed various truncated forms of FliC-EAEC based on its interaction site with TLR-5 and assessed the interactions via docking protocols. Then, the most appropriate truncated forms were PCR amplified, cloned in to pGEX-5X-1 plasmid and expressed. Finally, the expressed proteins were tested for pro-inflammatory properties. Our in silico and in vitro results indicated that two truncated forms of FliC- EAEC (amino acids 79-117 and 477-508) effectively interact with TLR-5, thus could be capable of inducing in vivo immune responses." @default.
- W2022192565 created "2016-06-24" @default.
- W2022192565 creator A5014092450 @default.
- W2022192565 creator A5027990453 @default.
- W2022192565 creator A5056466713 @default.
- W2022192565 creator A5082198631 @default.
- W2022192565 date "2013-06-13" @default.
- W2022192565 modified "2023-09-24" @default.
- W2022192565 title "In Silico and In Vitro Studies of Truncated Forms of Flagellin (FliC) of Enteroaggregative Escherichia coli (EAEC)" @default.
- W2022192565 cites W1519633296 @default.
- W2022192565 cites W1540453462 @default.
- W2022192565 cites W1646413467 @default.
- W2022192565 cites W1930598094 @default.
- W2022192565 cites W1940453590 @default.
- W2022192565 cites W1966892322 @default.
- W2022192565 cites W1972449088 @default.
- W2022192565 cites W1976927528 @default.
- W2022192565 cites W1978897589 @default.
- W2022192565 cites W1992192767 @default.
- W2022192565 cites W1995744610 @default.
- W2022192565 cites W2015642465 @default.
- W2022192565 cites W2020040553 @default.
- W2022192565 cites W2036657458 @default.
- W2022192565 cites W2037312364 @default.
- W2022192565 cites W2037863616 @default.
- W2022192565 cites W2048214746 @default.
- W2022192565 cites W2053043145 @default.
- W2022192565 cites W2053246453 @default.
- W2022192565 cites W2055043387 @default.
- W2022192565 cites W2074986801 @default.
- W2022192565 cites W2075948284 @default.
- W2022192565 cites W2106154817 @default.
- W2022192565 cites W2111593523 @default.
- W2022192565 cites W2114737175 @default.
- W2022192565 cites W2120592972 @default.
- W2022192565 cites W2126953691 @default.
- W2022192565 cites W2130501069 @default.
- W2022192565 cites W2134156588 @default.
- W2022192565 cites W2139981177 @default.
- W2022192565 cites W2141449280 @default.
- W2022192565 cites W2149723200 @default.
- W2022192565 cites W2155692711 @default.
- W2022192565 cites W2156849089 @default.
- W2022192565 cites W2159923852 @default.
- W2022192565 cites W2163451350 @default.
- W2022192565 cites W2169238760 @default.
- W2022192565 cites W2171778773 @default.
- W2022192565 cites W2326363347 @default.
- W2022192565 doi "https://doi.org/10.1002/minf.201300025" @default.
- W2022192565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27480063" @default.
- W2022192565 hasPublicationYear "2013" @default.
- W2022192565 type Work @default.
- W2022192565 sameAs 2022192565 @default.
- W2022192565 citedByCount "3" @default.
- W2022192565 countsByYear W20221925652014 @default.
- W2022192565 countsByYear W20221925652018 @default.
- W2022192565 countsByYear W20221925652020 @default.
- W2022192565 crossrefType "journal-article" @default.
- W2022192565 hasAuthorship W2022192565A5014092450 @default.
- W2022192565 hasAuthorship W2022192565A5027990453 @default.
- W2022192565 hasAuthorship W2022192565A5056466713 @default.
- W2022192565 hasAuthorship W2022192565A5082198631 @default.
- W2022192565 hasConcept C104317684 @default.
- W2022192565 hasConcept C136449434 @default.
- W2022192565 hasConcept C202751555 @default.
- W2022192565 hasConcept C203014093 @default.
- W2022192565 hasConcept C22744801 @default.
- W2022192565 hasConcept C2775905019 @default.
- W2022192565 hasConcept C2777587559 @default.
- W2022192565 hasConcept C2777863537 @default.
- W2022192565 hasConcept C2778910516 @default.
- W2022192565 hasConcept C38117629 @default.
- W2022192565 hasConcept C40767141 @default.
- W2022192565 hasConcept C523546767 @default.
- W2022192565 hasConcept C54355233 @default.
- W2022192565 hasConcept C547475151 @default.
- W2022192565 hasConcept C55493867 @default.
- W2022192565 hasConcept C86803240 @default.
- W2022192565 hasConcept C8891405 @default.
- W2022192565 hasConcept C89423630 @default.
- W2022192565 hasConceptScore W2022192565C104317684 @default.
- W2022192565 hasConceptScore W2022192565C136449434 @default.
- W2022192565 hasConceptScore W2022192565C202751555 @default.
- W2022192565 hasConceptScore W2022192565C203014093 @default.
- W2022192565 hasConceptScore W2022192565C22744801 @default.
- W2022192565 hasConceptScore W2022192565C2775905019 @default.
- W2022192565 hasConceptScore W2022192565C2777587559 @default.
- W2022192565 hasConceptScore W2022192565C2777863537 @default.
- W2022192565 hasConceptScore W2022192565C2778910516 @default.
- W2022192565 hasConceptScore W2022192565C38117629 @default.
- W2022192565 hasConceptScore W2022192565C40767141 @default.
- W2022192565 hasConceptScore W2022192565C523546767 @default.
- W2022192565 hasConceptScore W2022192565C54355233 @default.
- W2022192565 hasConceptScore W2022192565C547475151 @default.
- W2022192565 hasConceptScore W2022192565C55493867 @default.
- W2022192565 hasConceptScore W2022192565C86803240 @default.
- W2022192565 hasConceptScore W2022192565C8891405 @default.
- W2022192565 hasConceptScore W2022192565C89423630 @default.
- W2022192565 hasFunder F4320326567 @default.
- W2022192565 hasLocation W20221925651 @default.