FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022194304> ?p ?o ?g. }

• W2022194304 endingPage "61" @default.
• W2022194304 startingPage "57" @default.
• W2022194304 abstract "We tested whether alterations in membrane lipid composition associated with peroxisomal diseases affect muscarinic cholinergic signal transduction activity and amyloid precursor protein (APP) secretion in cultured human skin fibroblasts and Chinese hamster ovary (CHO) mutants. We found that in cell lines from patients with peroxisomal disorders where plasmalogen levels were low, the low-Km GTPase activity was not induced by carbachol, and APP secretion was reduced. This effect on signal transduction activity was not associated with decreased levels of the M1-muscarinic cholinergic receptor or its associated heterotrimeric G-protein. Specifically, this decrease was associated with a plasmalogen deficiency since a CHO cell line with only a deficit in plasmalogens was as severely affected as were generalized peroxisomal disorder cell lines. Thus, plasmalogens appear to be implicated in muscarinic cholinergic signal transduction and secretion of APP. These results provide new insights about the pathophysiology of peroxisomal diseases and may be relevant to Alzheimer's disease where reduced plasmalogen levels have been reported." @default.
• W2022194304 created "2016-06-24" @default.
• W2022194304 creator A5011945785 @default.
• W2022194304 creator A5036305131 @default.
• W2022194304 creator A5043431442 @default.
• W2022194304 creator A5059798104 @default.
• W2022194304 creator A5084355212 @default.
• W2022194304 creator A5091858941 @default.
• W2022194304 date "1998-07-01" @default.
• W2022194304 modified "2023-10-14" @default.
• W2022194304 title "Peroxisomal Disease Cell Lines with Cellular Plasmalogen Deficiency Have Impaired Muscarinic Cholinergic Signal Transduction Activity and Amyloid Precursor Protein Secretion" @default.
• W2022194304 cites W1503926813 @default.
• W2022194304 cites W1574033922 @default.
• W2022194304 cites W1964972074 @default.
• W2022194304 cites W1980749733 @default.
• W2022194304 cites W1982134056 @default.
• W2022194304 cites W1990543766 @default.
• W2022194304 cites W1993079087 @default.
• W2022194304 cites W1995954863 @default.
• W2022194304 cites W2001318724 @default.
• W2022194304 cites W2007960243 @default.
• W2022194304 cites W2025104020 @default.
• W2022194304 cites W2038902299 @default.
• W2022194304 cites W2040021502 @default.
• W2022194304 cites W2045810250 @default.
• W2022194304 cites W2053542471 @default.
• W2022194304 cites W2061562298 @default.
• W2022194304 cites W2064075440 @default.
• W2022194304 cites W2066713988 @default.
• W2022194304 cites W2073046289 @default.
• W2022194304 cites W2074228766 @default.
• W2022194304 cites W2087747373 @default.
• W2022194304 cites W2092362067 @default.
• W2022194304 cites W2148069328 @default.
• W2022194304 cites W2167428799 @default.
• W2022194304 cites W2186476960 @default.
• W2022194304 cites W2210030840 @default.
• W2022194304 cites W2314133009 @default.
• W2022194304 doi "https://doi.org/10.1006/bbrc.1998.8909" @default.
• W2022194304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9675085" @default.
• W2022194304 hasPublicationYear "1998" @default.
• W2022194304 type Work @default.
• W2022194304 sameAs 2022194304 @default.
• W2022194304 citedByCount "36" @default.
• W2022194304 countsByYear W20221943042012 @default.
• W2022194304 countsByYear W20221943042013 @default.
• W2022194304 countsByYear W20221943042015 @default.
• W2022194304 countsByYear W20221943042016 @default.
• W2022194304 countsByYear W20221943042017 @default.
• W2022194304 countsByYear W20221943042018 @default.
• W2022194304 countsByYear W20221943042019 @default.
• W2022194304 countsByYear W20221943042020 @default.
• W2022194304 countsByYear W20221943042021 @default.
• W2022194304 crossrefType "journal-article" @default.
• W2022194304 hasAuthorship W2022194304A5011945785 @default.
• W2022194304 hasAuthorship W2022194304A5036305131 @default.
• W2022194304 hasAuthorship W2022194304A5043431442 @default.
• W2022194304 hasAuthorship W2022194304A5059798104 @default.
• W2022194304 hasAuthorship W2022194304A5084355212 @default.
• W2022194304 hasAuthorship W2022194304A5091858941 @default.
• W2022194304 hasConcept C126322002 @default.
• W2022194304 hasConcept C134018914 @default.
• W2022194304 hasConcept C170493617 @default.
• W2022194304 hasConcept C22885893 @default.
• W2022194304 hasConcept C24998067 @default.
• W2022194304 hasConcept C2777565452 @default.
• W2022194304 hasConcept C2778918659 @default.
• W2022194304 hasConcept C2778988552 @default.
• W2022194304 hasConcept C33789571 @default.
• W2022194304 hasConcept C41625074 @default.
• W2022194304 hasConcept C55493867 @default.
• W2022194304 hasConcept C62478195 @default.
• W2022194304 hasConcept C71924100 @default.
• W2022194304 hasConcept C86803240 @default.
• W2022194304 hasConcept C95444343 @default.
• W2022194304 hasConceptScore W2022194304C126322002 @default.
• W2022194304 hasConceptScore W2022194304C134018914 @default.
• W2022194304 hasConceptScore W2022194304C170493617 @default.
• W2022194304 hasConceptScore W2022194304C22885893 @default.
• W2022194304 hasConceptScore W2022194304C24998067 @default.
• W2022194304 hasConceptScore W2022194304C2777565452 @default.
• W2022194304 hasConceptScore W2022194304C2778918659 @default.
• W2022194304 hasConceptScore W2022194304C2778988552 @default.
• W2022194304 hasConceptScore W2022194304C33789571 @default.
• W2022194304 hasConceptScore W2022194304C41625074 @default.
• W2022194304 hasConceptScore W2022194304C55493867 @default.
• W2022194304 hasConceptScore W2022194304C62478195 @default.
• W2022194304 hasConceptScore W2022194304C71924100 @default.
• W2022194304 hasConceptScore W2022194304C86803240 @default.
• W2022194304 hasConceptScore W2022194304C95444343 @default.
• W2022194304 hasIssue "1" @default.
• W2022194304 hasLocation W20221943041 @default.
• W2022194304 hasLocation W20221943042 @default.
• W2022194304 hasOpenAccess W2022194304 @default.
• W2022194304 hasPrimaryLocation W20221943041 @default.
• W2022194304 hasRelatedWork W1901275661 @default.
• W2022194304 hasRelatedWork W1970289512 @default.
• W2022194304 hasRelatedWork W1972099714 @default.

• next