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- W2022194631 abstract "The relationships between expiratory flowrates (V̇), pleural pressure (Ppl) and lung static recoil pressure (Pst) in a respiratory system with symmetrical and compliant bronchial tree are studied theoretically. Like in the other models of respiratory mechanics published so far, the relationship between V̇, Ppl and Pst is supposed to be unique and volumetric flow at the mouth to be equal to alveolar flow (the volumetric flow in the alveoles). No assumptions are introduced concerning the exact analytical form of the functions which describe the compliance characteristics of the airways or the regime of gas flow. It is shown that a compliant tube traversed by a flow may be either in stable or in unstable equilibrium. In stable conditions, there is necessarily a positive effort-dependency between V and Ppl, i.e. δV/δPpl > 0, and Pst is always a more effective driving pressure than Ppl. When the flow rates become nearly independent of Ppl, i.e. when δV/δPpl → 0, they approach a maximum value, whereas (δV̇/δPst tends towards a definite limit, different from zero, which determines the slope of a maximum expiratory flow-volume curve. Finally, when δV/δPpl = 0, i.e. when the flows are really effort-independent, the airways are necessarily unstable and collapse. Simultaneously, the flow generated by the collapsing airways can no longer be neglected with respect to alveolar flow: the unique relationship between V̇, Pst and Ppl cannot be maintained. This defines a limit of validity for the present analysis and for the various models of respiratory mechanics entering into the frame of this study. The results of the present theory, compared with the available experimental evidence, suggest that there exist mechanisms stabilizing the airways during forced expiration and preventing complete airway collapse." @default.
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- W2022194631 date "1973-10-01" @default.
- W2022194631 modified "2023-09-27" @default.
- W2022194631 title "A general theory of respiratory mechanics applied to forced expiration" @default.
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- W2022194631 doi "https://doi.org/10.1016/0034-5687(73)90090-x" @default.
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