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• W2022195521 abstract "Odorant responsiveness of a mouse olfactory receptor, mOR-EG, was investigated in various heterologous cells using a variety of detection methods. Odorant-induced Ca2+ response was observed in HEK293 cells that coexpressed mOR-EG and the promiscuous G protein, Gα15. Without Gα15, a robust increase in cAMP level was observed upon odorant-stimulation in various mammalian cells. A luciferase reporter gene assay using zif268 promoter was adopted to amplify the cAMP signals. In Xenopus laevis oocytes, odorant-stimulated currents were recorded when mOR-EG cRNA was co-injected with either Gα15 or cAMP-dependent channel. These results suggest that odorant responsiveness can be monitored via a signaling pathway mediated by endogenous Gαs or transfected Gα15 in heterologous cell systems. Various functional assays for a heterologously expressed olfactory receptor reported in this study, are potentially useful for high-throughput ligand screening and functional analyses of hundreds of olfactory receptors." @default.
• W2022195521 created "2016-06-24" @default.
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• W2022195521 date "2003-06-01" @default.
• W2022195521 modified "2023-10-11" @default.
• W2022195521 title "Odorant response assays for a heterologously expressed olfactory receptor" @default.
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• W2022195521 doi "https://doi.org/10.1016/s0006-291x(03)00863-5" @default.
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