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• W2022196368 abstract "During pregnancy several maternal and fetal mechanisms are established to prevent a destructive immune response against the allogeneic fetus. Despite these mechanisms, fetus specific T-cells persist throughout gestation but little is known about the regulation of these T-cells. Recently, CD4+CD25+ regulatory T-cells have been identified in human decidua. Human decidua forms the maternal part of the fetal–maternal interface and is subdivided in two distinct regions: the decidua (d.) basalis and the decidua (d.) parietalis. The aim of this study was to determine the distribution of specific T-cell subsets in d. basalis and d. parietalis in early and term pregnancy, with a special emphasis on the presence of CD4+CD25bright (regulatory) T-cells and CD8+CD28− (suppressor) T-cells. In addition, we compared phenotypic characteristics of decidua derived T-cell subsets with maternal peripheral blood (mPBL) T-cells and T-cells from non-pregnant controls. We identified significantly higher percentages of CD4+CD25bright and CD8+CD28− T-cells in decidua compared to peripheral blood suggesting an important role for these T-cell subsets locally at the fetal–maternal interface. The major differences in T-cell subset distribution and the presence of additional phenotypic differences between T-cells in d. basalis, d. parietalis and mPBL may reflect specific immunomodulatory functions of these T-cell subsets at these different sites during pregnancy." @default.
• W2022196368 created "2016-06-24" @default.
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• W2022196368 date "2006-04-01" @default.
• W2022196368 modified "2023-10-17" @default.
• W2022196368 title "Differential Distribution of CD4+CD25bright and CD8+CD28− T-cells in Decidua and Maternal Blood During Human Pregnancy" @default.
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• W2022196368 doi "https://doi.org/10.1016/j.placenta.2005.11.008" @default.
• W2022196368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16442616" @default.
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