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- W2022196959 endingPage "e1000604" @default.
- W2022196959 startingPage "e1000604" @default.
- W2022196959 abstract "Synaptic activity can boost neuroprotection through a mechanism that requires synapse-to-nucleus communication and calcium signals in the cell nucleus. Here we show that in hippocampal neurons nuclear calcium is one of the most potent signals in neuronal gene expression. The induction or repression of 185 neuronal activity-regulated genes is dependent upon nuclear calcium signaling. The nuclear calcium-regulated gene pool contains a genomic program that mediates synaptic activity-induced, acquired neuroprotection. The core set of neuroprotective genes consists of 9 principal components, termed Activity-regulated Inhibitor of Death (AID) genes, and includes Atf3, Btg2, GADD45β, GADD45γ, Inhibin β-A, Interferon activated gene 202B, Npas4, Nr4a1, and Serpinb2, which strongly promote survival of cultured hippocampal neurons. Several AID genes provide neuroprotection through a common process that renders mitochondria more resistant to cellular stress and toxic insults. Stereotaxic delivery of AID gene-expressing recombinant adeno-associated viruses to the hippocampus confers protection in vivo against seizure-induced brain damage. Thus, treatments that enhance nuclear calcium signaling or supplement AID genes represent novel therapies to combat neurodegenerative conditions and neuronal cell loss caused by synaptic dysfunction, which may be accompanied by a deregulation of calcium signal initiation and/or propagation to the cell nucleus." @default.
- W2022196959 created "2016-06-24" @default.
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- W2022196959 creator A5089844492 @default.
- W2022196959 date "2009-08-14" @default.
- W2022196959 modified "2023-10-13" @default.
- W2022196959 title "Nuclear Calcium Signaling Controls Expression of a Large Gene Pool: Identification of a Gene Program for Acquired Neuroprotection Induced by Synaptic Activity" @default.
- W2022196959 cites W1481834866 @default.
- W2022196959 cites W1488872763 @default.
- W2022196959 cites W1585306115 @default.
- W2022196959 cites W1625124567 @default.
- W2022196959 cites W1657916616 @default.
- W2022196959 cites W1918117223 @default.
- W2022196959 cites W1964483580 @default.
- W2022196959 cites W1967463041 @default.
- W2022196959 cites W1972476811 @default.
- W2022196959 cites W1973417580 @default.
- W2022196959 cites W1977956545 @default.
- W2022196959 cites W1980750700 @default.
- W2022196959 cites W1981364887 @default.
- W2022196959 cites W1984924722 @default.
- W2022196959 cites W1988181440 @default.
- W2022196959 cites W1992476409 @default.
- W2022196959 cites W1993050097 @default.
- W2022196959 cites W1993220836 @default.
- W2022196959 cites W1993335821 @default.
- W2022196959 cites W1994109113 @default.
- W2022196959 cites W2000240015 @default.
- W2022196959 cites W2002217566 @default.
- W2022196959 cites W2006277234 @default.
- W2022196959 cites W2006569015 @default.
- W2022196959 cites W2006777504 @default.
- W2022196959 cites W2007570855 @default.
- W2022196959 cites W2014764883 @default.
- W2022196959 cites W2022452425 @default.
- W2022196959 cites W2023200476 @default.
- W2022196959 cites W2023373433 @default.
- W2022196959 cites W2026524798 @default.
- W2022196959 cites W2030575711 @default.
- W2022196959 cites W2036268120 @default.
- W2022196959 cites W2036650593 @default.
- W2022196959 cites W2044470670 @default.
- W2022196959 cites W2047439767 @default.
- W2022196959 cites W2048201722 @default.
- W2022196959 cites W2051474146 @default.
- W2022196959 cites W2053544091 @default.
- W2022196959 cites W2056007810 @default.
- W2022196959 cites W2058132810 @default.
- W2022196959 cites W2059223526 @default.
- W2022196959 cites W2061412811 @default.
- W2022196959 cites W2062045688 @default.
- W2022196959 cites W2063541383 @default.
- W2022196959 cites W2064641679 @default.
- W2022196959 cites W2073961641 @default.
- W2022196959 cites W2075173841 @default.
- W2022196959 cites W2076199082 @default.
- W2022196959 cites W2081070804 @default.
- W2022196959 cites W2083630984 @default.
- W2022196959 cites W2086613181 @default.
- W2022196959 cites W2094019443 @default.
- W2022196959 cites W2094182857 @default.
- W2022196959 cites W2095435531 @default.
- W2022196959 cites W2096123613 @default.
- W2022196959 cites W2097586258 @default.
- W2022196959 cites W2098296304 @default.
- W2022196959 cites W2098712005 @default.
- W2022196959 cites W2098854209 @default.
- W2022196959 cites W2102450081 @default.
- W2022196959 cites W2104811781 @default.
- W2022196959 cites W2106726734 @default.
- W2022196959 cites W2109972881 @default.
- W2022196959 cites W2110831253 @default.
- W2022196959 cites W2112364230 @default.
- W2022196959 cites W2123701707 @default.
- W2022196959 cites W2124366353 @default.
- W2022196959 cites W2129011493 @default.
- W2022196959 cites W2133850147 @default.
- W2022196959 cites W2145330934 @default.
- W2022196959 cites W2150665874 @default.
- W2022196959 cites W2159030157 @default.
- W2022196959 cites W2160855812 @default.
- W2022196959 cites W2163383917 @default.
- W2022196959 cites W2165008864 @default.
- W2022196959 cites W2314493329 @default.
- W2022196959 cites W2321725396 @default.
- W2022196959 cites W491163643 @default.
- W2022196959 cites W6340190 @default.
- W2022196959 doi "https://doi.org/10.1371/journal.pgen.1000604" @default.
- W2022196959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2718706" @default.
- W2022196959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19680447" @default.
- W2022196959 hasPublicationYear "2009" @default.