FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022197180> ?p ?o ?g. }

• W2022197180 endingPage "53" @default.
• W2022197180 startingPage "42" @default.
• W2022197180 abstract "Nitric oxide (NO) plays key roles in vasodilation and host defense, yet the overproduction of NO by inducible nitric oxide synthase (iNOS) at inflammatory sites can also be pathogenic. Here, we investigate the role of MPO in modulating the induction of iNOS by IFNγ/LPS (IL). In monocyte–macrophages (Mϕ) treated with IL, MPO gene expression was found to be downregulated as iNOS was upregulated. In Mϕ from MPO-knockout (KO) mice, the induction of iNOS by IL was earlier and higher than in MPO-positive cells, suggesting MPO is inhibitory. Consistent with that interpretation, the addition of purified MPO enzyme to cultured macrophages inhibited iNOS induction by IL. In addition, an inhibitor of MPO enzyme, 4-aminobenzohydrazide, enhanced iNOS induction in MPO-positive cells, but not in MPO-KO cells. Similarly, taurine, a scavenger of MPO-generated HOCl, enhanced iNOS induction in MPO-positive cells, but not in MPO-KO cells. MPO affects an early event, suppressing iNOS induction when added within 2 h of IL, but not when added several hours after IL. The suppression by MPO was alleviated by NO donor, sodium nitroprusside, suggesting the suppression results from scavenging of NO by MPO. This interpretation is consistent with earlier reports that MPO consumes NO, and that low levels of NO donor augment induction of iNOS by IFNγ/LPS. The implication of these findings is that MPO acts as gatekeeper, suppressing the deleterious induction of iNOS at inflammatory sites by illegitimate signals. The combined signaling of IFNγ/LPS overrides the gatekeeper function by suppressing MPO gene expression." @default.
• W2022197180 created "2016-06-24" @default.
• W2022197180 creator A5029812789 @default.
• W2022197180 creator A5033553910 @default.
• W2022197180 creator A5042507086 @default.
• W2022197180 creator A5058193427 @default.
• W2022197180 date "2005-08-01" @default.
• W2022197180 modified "2023-10-03" @default.
• W2022197180 title "Inducible nitric oxide synthase expression is inhibited by myeloperoxidase" @default.
• W2022197180 cites W1486705747 @default.
• W2022197180 cites W1487326635 @default.
• W2022197180 cites W1560571961 @default.
• W2022197180 cites W1562045776 @default.
• W2022197180 cites W1591881963 @default.
• W2022197180 cites W1596698400 @default.
• W2022197180 cites W176107634 @default.
• W2022197180 cites W1772269777 @default.
• W2022197180 cites W1915851248 @default.
• W2022197180 cites W1964457547 @default.
• W2022197180 cites W1966120931 @default.
• W2022197180 cites W1972396934 @default.
• W2022197180 cites W1972824411 @default.
• W2022197180 cites W1977662482 @default.
• W2022197180 cites W1985404699 @default.
• W2022197180 cites W1985929162 @default.
• W2022197180 cites W1989409713 @default.
• W2022197180 cites W1992415335 @default.
• W2022197180 cites W1997005279 @default.
• W2022197180 cites W1999044236 @default.
• W2022197180 cites W2010649278 @default.
• W2022197180 cites W2012677944 @default.
• W2022197180 cites W2013204959 @default.
• W2022197180 cites W2018992923 @default.
• W2022197180 cites W2028257547 @default.
• W2022197180 cites W2031533866 @default.
• W2022197180 cites W2031967567 @default.
• W2022197180 cites W2033525453 @default.
• W2022197180 cites W2039406268 @default.
• W2022197180 cites W2040443301 @default.
• W2022197180 cites W2045502875 @default.
• W2022197180 cites W2047932752 @default.
• W2022197180 cites W2051061580 @default.
• W2022197180 cites W2057297466 @default.
• W2022197180 cites W2071544912 @default.
• W2022197180 cites W2075034126 @default.
• W2022197180 cites W2080515968 @default.
• W2022197180 cites W2085430726 @default.
• W2022197180 cites W2088757784 @default.
• W2022197180 cites W2105936580 @default.
• W2022197180 cites W2108494929 @default.
• W2022197180 cites W2114490800 @default.
• W2022197180 cites W2117667204 @default.
• W2022197180 cites W2118480498 @default.
• W2022197180 cites W2121817707 @default.
• W2022197180 cites W2125064850 @default.
• W2022197180 cites W2125605952 @default.
• W2022197180 cites W2132575805 @default.
• W2022197180 cites W2133040336 @default.
• W2022197180 cites W2134551277 @default.
• W2022197180 cites W2135694413 @default.
• W2022197180 cites W2137623306 @default.
• W2022197180 cites W2142527036 @default.
• W2022197180 cites W2144109738 @default.
• W2022197180 cites W2149200346 @default.
• W2022197180 cites W2165280103 @default.
• W2022197180 cites W2169462078 @default.
• W2022197180 cites W2183356613 @default.
• W2022197180 cites W2336202838 @default.
• W2022197180 cites W2341049818 @default.
• W2022197180 cites W2341768699 @default.
• W2022197180 cites W346538768 @default.
• W2022197180 cites W4230038264 @default.
• W2022197180 doi "https://doi.org/10.1016/j.niox.2005.04.002" @default.
• W2022197180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15893945" @default.
• W2022197180 hasPublicationYear "2005" @default.
• W2022197180 type Work @default.
• W2022197180 sameAs 2022197180 @default.
• W2022197180 citedByCount "32" @default.
• W2022197180 countsByYear W20221971802012 @default.
• W2022197180 countsByYear W20221971802013 @default.
• W2022197180 countsByYear W20221971802015 @default.
• W2022197180 countsByYear W20221971802016 @default.
• W2022197180 countsByYear W20221971802017 @default.
• W2022197180 countsByYear W20221971802018 @default.
• W2022197180 countsByYear W20221971802019 @default.
• W2022197180 countsByYear W20221971802020 @default.
• W2022197180 countsByYear W20221971802022 @default.
• W2022197180 crossrefType "journal-article" @default.
• W2022197180 hasAuthorship W2022197180A5029812789 @default.
• W2022197180 hasAuthorship W2022197180A5033553910 @default.
• W2022197180 hasAuthorship W2022197180A5042507086 @default.
• W2022197180 hasAuthorship W2022197180A5058193427 @default.
• W2022197180 hasConcept C153911025 @default.
• W2022197180 hasConcept C178790620 @default.
• W2022197180 hasConcept C181199279 @default.
• W2022197180 hasConcept C185592680 @default.
• W2022197180 hasConcept C202751555 @default.
• W2022197180 hasConcept C203014093 @default.

• next