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- W2022197597 abstract "Nociceptin/orphanin FQ (nociceptin/OFQ), a newly discovered heptadecapeptide has been regarded as an endogenous ligand for orphan opioid receptor. The present study was designed to investigate the effect of nociceptin/OFQ on pain response and opioid analgesia in the rat formalin test. The results showed that intracerebroventricular injection of 1 μg nociceptin/OFQ enhanced the pain response, and 0.1 or 0.5 μg nociceptin/OFQ had no effect on formalin-induced pain. When 0.1 or 1 μg nociceptin/OFQ were used together with μ-, δ-, or κ-opioid receptor agonists, endomorphin-1, DSLET or U50488H, respectively, it attenuated μ- and κ- but not δ-receptor mediated analgesia. On the other hand, intrathecal injection of nociceptin/OFQ (0.1, 1 and 5 μg) reduced the pain response in the formalin test. In conclusion, nociceptin/OFQ potentiated formalin-induced pain response and antagonized opioid analgesia in the rat brain but inhibited pain response in the spinal cord." @default.
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- W2022197597 date "1999-02-01" @default.
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- W2022197597 title "Distinct effect of intracerebroventricular and intrathecal injections of nociceptin/orphanin FQ in the rat formalin test" @default.
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- W2022197597 doi "https://doi.org/10.1016/s0167-0115(98)00161-x" @default.
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