Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022200209> ?p ?o ?g. }
- W2022200209 endingPage "38" @default.
- W2022200209 startingPage "33" @default.
- W2022200209 abstract "Pleiotropic effects of resveratrol include antioxidant activity and inhibition of cyclooxygenase with decrease of PGE2 formation. In erythrocytes oxidation and PGE2 activate Ca2+-permeable cation channels. The Ca2+-entry leads to activation of Ca2+-sensitive K+ channels with subsequent cell shrinkage and cell membrane scrambling with phosphatidylserine exposure at the erythrocyte surface. Cell shrinkage and phosphatidylserine exposure are hallmarks of suicidal erythrocyte death or eryptosis. Eryptotic cells adhere to the vascular wall thus compromising microcirculation and are cleared from circulating blood thus leading to anemia. The present experiments explored whether resveratrol influences eryptosis. Erythrocyte phosphatidylserine exposure was identified by annexin V-binding, cell volume estimated from forward scatter and cytosolic Ca2+ activity determined utilizing Fluo3 fluorescence in FACS analysis. Energy depletion (48 h glucose removal) significantly increased Fluo3 fluorescence and annexin V-binding and decreased forward scatter, effects significantly blunted by resveratrol (≥ 5 µM). Moreover, oxidative stress (30 min 0.3 mM tert-butylhydroperoxide) and isoosmotic cell shrinkage (48 h replacement of extracellular chloride by gluconate) similarly triggered eryptosis, effects again significantly blunted in the presence of resveratrol. Resveratrol is a potent inhibitor of suicidal erythrocyte death during energy depletion, oxidative stress and isoosmotic cell shrinkage. The nutrient could thus counteract anemia and impairment of microcirculation under conditions with excessive eryptosis." @default.
- W2022200209 created "2016-06-24" @default.
- W2022200209 creator A5061162593 @default.
- W2022200209 creator A5065486769 @default.
- W2022200209 creator A5084208566 @default.
- W2022200209 date "2009-07-01" @default.
- W2022200209 modified "2023-09-27" @default.
- W2022200209 title "Inhibition of suicidal erythrocyte death by resveratrol" @default.
- W2022200209 cites W13114315 @default.
- W2022200209 cites W1490172408 @default.
- W2022200209 cites W1963571039 @default.
- W2022200209 cites W1964122661 @default.
- W2022200209 cites W1972748726 @default.
- W2022200209 cites W1974167394 @default.
- W2022200209 cites W1976466808 @default.
- W2022200209 cites W1979501382 @default.
- W2022200209 cites W1983943582 @default.
- W2022200209 cites W1984851725 @default.
- W2022200209 cites W1985265962 @default.
- W2022200209 cites W1986271732 @default.
- W2022200209 cites W1990356838 @default.
- W2022200209 cites W1992939609 @default.
- W2022200209 cites W1996497038 @default.
- W2022200209 cites W1997035621 @default.
- W2022200209 cites W1997519809 @default.
- W2022200209 cites W1997988948 @default.
- W2022200209 cites W2004482012 @default.
- W2022200209 cites W2007205802 @default.
- W2022200209 cites W2014189646 @default.
- W2022200209 cites W2016299124 @default.
- W2022200209 cites W2019471670 @default.
- W2022200209 cites W2024553502 @default.
- W2022200209 cites W2026523078 @default.
- W2022200209 cites W2029304666 @default.
- W2022200209 cites W2032354296 @default.
- W2022200209 cites W2036961219 @default.
- W2022200209 cites W2038819783 @default.
- W2022200209 cites W2039616271 @default.
- W2022200209 cites W2039659095 @default.
- W2022200209 cites W2040600751 @default.
- W2022200209 cites W2041605386 @default.
- W2022200209 cites W2042948104 @default.
- W2022200209 cites W2043119510 @default.
- W2022200209 cites W2044749442 @default.
- W2022200209 cites W2045148265 @default.
- W2022200209 cites W2045456454 @default.
- W2022200209 cites W2046126455 @default.
- W2022200209 cites W2046588089 @default.
- W2022200209 cites W2050571341 @default.
- W2022200209 cites W2051040462 @default.
- W2022200209 cites W2051520080 @default.
- W2022200209 cites W2052726190 @default.
- W2022200209 cites W2056369070 @default.
- W2022200209 cites W2061902383 @default.
- W2022200209 cites W2063162012 @default.
- W2022200209 cites W2065196084 @default.
- W2022200209 cites W2065641335 @default.
- W2022200209 cites W2068567462 @default.
- W2022200209 cites W2074728848 @default.
- W2022200209 cites W2075763304 @default.
- W2022200209 cites W2077719703 @default.
- W2022200209 cites W2078137514 @default.
- W2022200209 cites W2082361474 @default.
- W2022200209 cites W2088533769 @default.
- W2022200209 cites W2089281127 @default.
- W2022200209 cites W2089976554 @default.
- W2022200209 cites W2092025193 @default.
- W2022200209 cites W2093149218 @default.
- W2022200209 cites W2098000156 @default.
- W2022200209 cites W2102807564 @default.
- W2022200209 cites W2111439660 @default.
- W2022200209 cites W2113053099 @default.
- W2022200209 cites W2113615084 @default.
- W2022200209 cites W2119378143 @default.
- W2022200209 cites W2122881251 @default.
- W2022200209 cites W2131523916 @default.
- W2022200209 cites W2132855703 @default.
- W2022200209 cites W2135482855 @default.
- W2022200209 cites W2135664206 @default.
- W2022200209 cites W2141256837 @default.
- W2022200209 cites W2144669446 @default.
- W2022200209 cites W2148394321 @default.
- W2022200209 cites W2152736786 @default.
- W2022200209 cites W2155670471 @default.
- W2022200209 cites W2172224722 @default.
- W2022200209 cites W2317277068 @default.
- W2022200209 cites W2334570807 @default.
- W2022200209 cites W4236564357 @default.
- W2022200209 cites W4246488749 @default.
- W2022200209 doi "https://doi.org/10.1016/j.lfs.2009.04.015" @default.
- W2022200209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19409912" @default.
- W2022200209 hasPublicationYear "2009" @default.
- W2022200209 type Work @default.
- W2022200209 sameAs 2022200209 @default.
- W2022200209 citedByCount "29" @default.
- W2022200209 countsByYear W20222002092012 @default.
- W2022200209 countsByYear W20222002092013 @default.
- W2022200209 countsByYear W20222002092014 @default.