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• W2022200846 abstract "Abstract Background Chondrogenesis and subsequent endochondral ossification are processes tightly regulated by the transcription factor Sox9 (SRY-related high mobility group-Box gene 9), but molecular mechanisms underlying this activity remain unclear. Here we report that coactivator-associated arginine methyltransferase 1 (CARM1) regulates chondrocyte proliferation via arginine methylation of Sox9. Results CARM1-null mice display delayed endochondral ossification and decreased chondrocyte proliferation. Conversely, cartilage development of CARM1 transgenic mice was accelerated. CARM1 specifically methylates Sox9 at its HMG domain in vivo and in vitro . Arg-methylation of Sox9 by CARM1 disrupts interaction of Sox9 with beta-catenin, regulating Cyclin D1 expression and cell cycle progression of chondrocytes. Conclusion These results establish a role for CARM1 as an important regulator of chondrocyte proliferation during embryogenesis." @default.
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• W2022200846 date "2009-09-02" @default.
• W2022200846 modified "2023-10-12" @default.
• W2022200846 title "Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification" @default.
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• W2022200846 doi "https://doi.org/10.1186/1471-213x-9-47" @default.
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