Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022201291> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2022201291 endingPage "346" @default.
- W2022201291 startingPage "341" @default.
- W2022201291 abstract "ABSTRACT: Supplemental oxygen and alkalosis are the most effective treatments used to lower pulmonary arterial pressure in children with pulmonary hypertensive disorders. However, their mechanisms of action are unknown. Endothelium-derived nitric oxide (EDNO) is an important mediator of pulmonary vascular tone and produces potent pulmonary vasodilation during pulmonary hypertension.In vitro evidence suggests that EDNO may mediate the vasodilating effects of oxygen. To investigate whether EDNO synthesis mediates the pulmonary vasodilation produced by hyperoxia [normocarbic ventilation with 100% oxygen, arterial oxygen tension > 450 torr (60 kPa)] or alkalosis (hyperventilation with 21% oxygen, pH > 7.55)in vivo, eight intact newborn lambs were studied during similar degrees of pulmonary hypertension induced either by the infusion of U46619 (a thromboxane A2 mimic) or Nω-nitro-L-arginine (an inhibitor of EDNO synthesis). The lambs were sedated, paralyzed, and mechanically ventilated. Meclofenamic acid was infused to inhibit prostaglandin synthesis. During pulmonary hypertension induced by U46619, pulmonary arterial pressure and pulmonary vascular resistance were significantly decreased by acetylcholine (an EDNO-dependent vasodilator) (23.1 ± 3.4% and 43.3 ± 14.5%, respectively), hyperoxia (26.8 ± 7.8% and 32.9 ± 10.6%), and alkalosis (32.1 ± 10.3% and 36.1 ± 17.0%) (p < 0.05). During pulmonary hypertension induced by Nω-nitro-L-arginine, the decreases in pulmonary arterial pressure and pulmonary vascular resistance produced by acetylcholine (9.6 ± 6.4% and 23.9 ± 14.1%, respectively) were significantly attenuated (p < 0.05), but the decreases produced by hyperoxia or alkalosis were unchanged. Therefore, hyperoxia and alkalosis can produce pulmonary vasodilation independent of EDNO synthesis in the intact newborn lamb. (Pediatr Res 33: 341-346, 1993)" @default.
- W2022201291 created "2016-06-24" @default.
- W2022201291 creator A5020973440 @default.
- W2022201291 creator A5038882859 @default.
- W2022201291 creator A5040323150 @default.
- W2022201291 date "1993-04-01" @default.
- W2022201291 modified "2023-09-27" @default.
- W2022201291 title "Hyperoxia and Alkalosis Produce Pulmonary Vasodilation Independent of Endothelium-Derived Nitric Oxide in Newborn Lambs" @default.
- W2022201291 cites W2004513382 @default.
- W2022201291 doi "https://doi.org/10.1203/00006450-199304000-00007" @default.
- W2022201291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8479813" @default.
- W2022201291 hasPublicationYear "1993" @default.
- W2022201291 type Work @default.
- W2022201291 sameAs 2022201291 @default.
- W2022201291 citedByCount "10" @default.
- W2022201291 countsByYear W20222012912012 @default.
- W2022201291 countsByYear W20222012912014 @default.
- W2022201291 countsByYear W20222012912015 @default.
- W2022201291 countsByYear W20222012912019 @default.
- W2022201291 crossrefType "journal-article" @default.
- W2022201291 hasAuthorship W2022201291A5020973440 @default.
- W2022201291 hasAuthorship W2022201291A5038882859 @default.
- W2022201291 hasAuthorship W2022201291A5040323150 @default.
- W2022201291 hasBestOaLocation W20222012911 @default.
- W2022201291 hasConcept C120770815 @default.
- W2022201291 hasConcept C126322002 @default.
- W2022201291 hasConcept C178853913 @default.
- W2022201291 hasConcept C2777068682 @default.
- W2022201291 hasConcept C2777714996 @default.
- W2022201291 hasConcept C2778553927 @default.
- W2022201291 hasConcept C2779246250 @default.
- W2022201291 hasConcept C2780672939 @default.
- W2022201291 hasConcept C2780930700 @default.
- W2022201291 hasConcept C2780940725 @default.
- W2022201291 hasConcept C2781063116 @default.
- W2022201291 hasConcept C42219234 @default.
- W2022201291 hasConcept C519581460 @default.
- W2022201291 hasConcept C58245268 @default.
- W2022201291 hasConcept C71924100 @default.
- W2022201291 hasConcept C98274493 @default.
- W2022201291 hasConceptScore W2022201291C120770815 @default.
- W2022201291 hasConceptScore W2022201291C126322002 @default.
- W2022201291 hasConceptScore W2022201291C178853913 @default.
- W2022201291 hasConceptScore W2022201291C2777068682 @default.
- W2022201291 hasConceptScore W2022201291C2777714996 @default.
- W2022201291 hasConceptScore W2022201291C2778553927 @default.
- W2022201291 hasConceptScore W2022201291C2779246250 @default.
- W2022201291 hasConceptScore W2022201291C2780672939 @default.
- W2022201291 hasConceptScore W2022201291C2780930700 @default.
- W2022201291 hasConceptScore W2022201291C2780940725 @default.
- W2022201291 hasConceptScore W2022201291C2781063116 @default.
- W2022201291 hasConceptScore W2022201291C42219234 @default.
- W2022201291 hasConceptScore W2022201291C519581460 @default.
- W2022201291 hasConceptScore W2022201291C58245268 @default.
- W2022201291 hasConceptScore W2022201291C71924100 @default.
- W2022201291 hasConceptScore W2022201291C98274493 @default.
- W2022201291 hasIssue "4" @default.
- W2022201291 hasLocation W20222012911 @default.
- W2022201291 hasLocation W20222012912 @default.
- W2022201291 hasOpenAccess W2022201291 @default.
- W2022201291 hasPrimaryLocation W20222012911 @default.
- W2022201291 hasRelatedWork W1974928113 @default.
- W2022201291 hasRelatedWork W1977033090 @default.
- W2022201291 hasRelatedWork W2009332475 @default.
- W2022201291 hasRelatedWork W2022201291 @default.
- W2022201291 hasRelatedWork W2028882507 @default.
- W2022201291 hasRelatedWork W2047123591 @default.
- W2022201291 hasRelatedWork W2085283746 @default.
- W2022201291 hasRelatedWork W2116800673 @default.
- W2022201291 hasRelatedWork W2187161180 @default.
- W2022201291 hasRelatedWork W2441472761 @default.
- W2022201291 hasVolume "33" @default.
- W2022201291 isParatext "false" @default.
- W2022201291 isRetracted "false" @default.
- W2022201291 magId "2022201291" @default.
- W2022201291 workType "article" @default.