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- W2022201398 abstract "Non-protected 2,5-diketopiperazine derivatives have poor solubility thus with negative impact on their bioavailability. In the present study, twenty-one novel soluble mono-protected, and three non-protected 2,5-diketopiperazine derivatives were designed and synthesized. Their anticancer activity to ten cell lines were evaluated by using CCK8 assay, and the results showed that about half of the mono-protected derivatives had broad-spectrum anticancer activity. Among allyl-protected derivatives, compound 4m had strong activity to all the cell lines (IC50 = 0.5–4.5 μM), especially to the cancer cell lines U937 (IC50 = 0.5 μM) and K562 (IC50 = 0.9 μM). Compound 4m could become a lead compound for further development for anticancer agents." @default.
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- W2022201398 date "2014-08-01" @default.
- W2022201398 modified "2023-10-01" @default.
- W2022201398 title "Design and synthesis of novel soluble 2,5-diketopiperazine derivatives as potential anticancer agents" @default.
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- W2022201398 doi "https://doi.org/10.1016/j.ejmech.2014.06.030" @default.
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