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• W2022202114 abstract "The human calcium‐independent phospholipase A 2 (iPLA 2 ; 88 kDa) has recently been cloned (Larsson, P.K.A., Claesson, H.‐E. and Kennedy, B.P. (1998) J. Biol. Chem. 272, 207–214). Here we demonstrate the expression of the human iPLA 2 mRNA and its splice variants in blood progenitor cells, immature leukemic cells and mature granulocytes. Chromatographical resolvable iPLA 2 activity was found in the cytosolic fraction of granulocytes and the activity was inhibited by the iPLA 2 inhibitor bromoenol lactone. This drug also inhibited leukotriene synthesis in human granulocytes, induced by low concentration of calcium ionophore A23187 (0.10–0.15 μM) or opsonized zymosan. These results suggest that iPLA 2 is involved in the regulation of the pool of arachidonic acid destined for leukotriene synthesis in human granulocytes." @default.
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• W2022202114 date "1998-09-04" @default.
• W2022202114 modified "2023-09-30" @default.
• W2022202114 title "On the expression of cytosolic calcium-independent phospholipase A₂(88 kDa) in immature and mature myeloid cells and its role in leukotriene synthesis in human granulocytes" @default.
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• W2022202114 doi "https://doi.org/10.1016/s0014-5793(98)00999-5" @default.
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