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• W2022202894 abstract "We previously reported that a permanent transection of adult rat sciatic and hypoglossal nerves resulted in distinct changes in the levels of both low-affinity nerve growth factor receptor (p75) and choline acetyltransferase in the corresponding motoneurons as determined by immunoreactivity. Permanent axotomy of hypoglossal motoneurons induced a progressive loss of choline acetyltransferase immunoreactivity and a persistent expression of p75 immunoreactivity, phenomena that were not observed in spinal motoneurons. These observations indicated that spinal and brainstem motoneurons respond to permanent axotomy with a differential immunoreactivity for p75 and choline acetyltransferase. Such differences could be ascribed to specific intrinsic properties of each population of motoneurons or, alternatively, to different factors present in the periphery (nerve stump or target muscle). The aim of the present study was to test these two possibilities by determining if a segment of sciatic nerve transplanted to a transected hypoglossal nerve may counteract or attenuate the loss of choline acetyltransferase immunoreactivity in injured hypoglossal motoneurons. In addition, as further parameter, we analysed the presence of p75 immunoreactivity. Prior to grafting, segments of sciatic nerve were prepared by one of three methods: (i) a fresh piece; (ii) a degenerated piece; and (iii) a heated piece. Seven and 30 days following the placement of grafts, hypoglossal motoneurons were analysed for choline acetyltransferase and p75 immunolabelling. The results revealed that viable sciatic grafts (fresh and degenerated) are able to partially attenuate the loss in the number of choline acetyltransferase-positive injured hypoglossal motoneurons, even if an important decrease in choline acetyltransferase still persists with respect to the contralateral nucleus. In addition, viable sciatic grafts decreased the number of p75 immunoreactive hypoglossal motoneurons both at seven and at 30 days. In conclusion, the effects of viable sciatic grafts on the number of choline acetyltransferase and p75-labelled hypoglossal motoneurons indicate that these adult neurons are able to respond to factors released from the sciatic nerve, and that the number of injured motoneurons positive for choline acetyltransferase and p75 can be influenced by the presence of factors that may reach their proximal stumps. Furthermore, we hypothesize that the differential expression patterns between hypoglossal and sciatic motoneurons may be due, at least in part, to factors released from the nerve trunks themselves." @default.
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• W2022202894 date "1997-09-01" @default.
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• W2022202894 title "Effects of sciatic nerve grafts on choline acetyltransferase and p75 expression in transected adult hypoglossal motoneurons" @default.
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• W2022202894 doi "https://doi.org/10.1016/s0306-4522(97)00150-4" @default.
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