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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022203118> ?p ?o ?g. }

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• W2022203118 abstract "This paper reports the synthesis of a new series of 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones which were tested as potential antitumor agents at the National Cancer Institute. Two derivatives are now under review by BEC (Biological Evaluation Committee of NCI). To investigate the mechanism of action, the effect on cell cycle progression was studied by monitoring them in colon adenocarcinoma HT-29: both were able to block HT-29 in mitosis. 3-[(2,6-Dimethylimidazo[2,1-b]thiazol-5-yl)methylene]-5-chloro-2-indolinone was the most active compound." @default.
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• W2022203118 date "2005-07-28" @default.
• W2022203118 modified "2023-09-25" @default.
• W2022203118 title "Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-<i>b</i>]thiazolylmethylene)-2-indolinones and Study of Their Effect on the Cell Cycle" @default.
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• W2022203118 doi "https://doi.org/10.1021/jm050353e" @default.
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