Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022204279> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2022204279 endingPage "656" @default.
- W2022204279 startingPage "654" @default.
- W2022204279 abstract "The inadvertent combination of sildenafil (SLD) and nitric oxide releasing compounds (NRC) may cause a life threatening hypotension and conversion of coital angina into an irreversible one. The aim of this study was to develop and validate a UPLC MS/MS method for the simultaneous quantitative analysis of SLD, nicorandil (NRD), and ARG in human plasma to determine the safety margins for drug combinations.Chromatographic elution was achieved in 4min using gradient elution and an injection volume of 10μL. Electro-spray positive ionization (ESI+ve) detection and multiple-reaction monitoring mode (MRM) were used for detection.The method was found to be linear (10-900ng/mL for SLD and NRD while 1-30μg/mL for ARG), accurate and precise (99.35±1.58, 99.62±1.13, and 100.04±1.22% for SLD, NRD and ARG; respectively) and met all other validation requirements.The developed UPLC MS/MS method is suitable for fast, sensitive, accurate and simultaneous determinations of SLD, NRD, and ARG in plasma." @default.
- W2022204279 created "2016-06-24" @default.
- W2022204279 creator A5010673741 @default.
- W2022204279 creator A5069053279 @default.
- W2022204279 creator A5075252277 @default.
- W2022204279 creator A5089587821 @default.
- W2022204279 date "2014-05-01" @default.
- W2022204279 modified "2023-10-06" @default.
- W2022204279 title "Simultaneous determination of sildenafil citrate and some nitric oxide releasing drugs in human plasma using UPLC MS/MS" @default.
- W2022204279 cites W1569192650 @default.
- W2022204279 cites W1977291173 @default.
- W2022204279 cites W1988026208 @default.
- W2022204279 cites W1997286229 @default.
- W2022204279 cites W1999339514 @default.
- W2022204279 cites W2028361159 @default.
- W2022204279 cites W2078653778 @default.
- W2022204279 cites W2052225757 @default.
- W2022204279 doi "https://doi.org/10.1016/j.clinbiochem.2014.03.009" @default.
- W2022204279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24685593" @default.
- W2022204279 hasPublicationYear "2014" @default.
- W2022204279 type Work @default.
- W2022204279 sameAs 2022204279 @default.
- W2022204279 citedByCount "5" @default.
- W2022204279 countsByYear W20222042792016 @default.
- W2022204279 countsByYear W20222042792017 @default.
- W2022204279 countsByYear W20222042792020 @default.
- W2022204279 countsByYear W20222042792022 @default.
- W2022204279 crossrefType "journal-article" @default.
- W2022204279 hasAuthorship W2022204279A5010673741 @default.
- W2022204279 hasAuthorship W2022204279A5069053279 @default.
- W2022204279 hasAuthorship W2022204279A5075252277 @default.
- W2022204279 hasAuthorship W2022204279A5089587821 @default.
- W2022204279 hasConcept C126322002 @default.
- W2022204279 hasConcept C162356407 @default.
- W2022204279 hasConcept C179998833 @default.
- W2022204279 hasConcept C185592680 @default.
- W2022204279 hasConcept C2776768464 @default.
- W2022204279 hasConcept C2778902376 @default.
- W2022204279 hasConcept C3017686574 @default.
- W2022204279 hasConcept C3020134792 @default.
- W2022204279 hasConcept C31827203 @default.
- W2022204279 hasConcept C42219234 @default.
- W2022204279 hasConcept C43617362 @default.
- W2022204279 hasConcept C71043704 @default.
- W2022204279 hasConcept C71924100 @default.
- W2022204279 hasConcept C73826308 @default.
- W2022204279 hasConceptScore W2022204279C126322002 @default.
- W2022204279 hasConceptScore W2022204279C162356407 @default.
- W2022204279 hasConceptScore W2022204279C179998833 @default.
- W2022204279 hasConceptScore W2022204279C185592680 @default.
- W2022204279 hasConceptScore W2022204279C2776768464 @default.
- W2022204279 hasConceptScore W2022204279C2778902376 @default.
- W2022204279 hasConceptScore W2022204279C3017686574 @default.
- W2022204279 hasConceptScore W2022204279C3020134792 @default.
- W2022204279 hasConceptScore W2022204279C31827203 @default.
- W2022204279 hasConceptScore W2022204279C42219234 @default.
- W2022204279 hasConceptScore W2022204279C43617362 @default.
- W2022204279 hasConceptScore W2022204279C71043704 @default.
- W2022204279 hasConceptScore W2022204279C71924100 @default.
- W2022204279 hasConceptScore W2022204279C73826308 @default.
- W2022204279 hasIssue "7-8" @default.
- W2022204279 hasLocation W20222042791 @default.
- W2022204279 hasLocation W20222042792 @default.
- W2022204279 hasOpenAccess W2022204279 @default.
- W2022204279 hasPrimaryLocation W20222042791 @default.
- W2022204279 hasRelatedWork W1972058654 @default.
- W2022204279 hasRelatedWork W2002310001 @default.
- W2022204279 hasRelatedWork W2060766171 @default.
- W2022204279 hasRelatedWork W2079683778 @default.
- W2022204279 hasRelatedWork W2086461136 @default.
- W2022204279 hasRelatedWork W2108446806 @default.
- W2022204279 hasRelatedWork W2426992577 @default.
- W2022204279 hasRelatedWork W2439506609 @default.
- W2022204279 hasRelatedWork W2477557873 @default.
- W2022204279 hasRelatedWork W2994188593 @default.
- W2022204279 hasVolume "47" @default.
- W2022204279 isParatext "false" @default.
- W2022204279 isRetracted "false" @default.
- W2022204279 magId "2022204279" @default.
- W2022204279 workType "article" @default.