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- W2022204328 abstract "Sphingosylphosphatidylcholine (SPC) is metabolized from sphingomyelin (SM) of a minor cell membrane phospholipid during the apoptosis and the hyperlipidemia. Lysophosphatidylcholine (LPC) is produced from phosphatidylcholine (PC) of a major membrane phospholipid during the ischemia. These lipid metabolites are known to modify a variety of ion channels. In the present study, we examined in detail with the planar lipid bilayer method how the cardiac RyR channels are modified by SPC and LPC. The cis-side addition of SPC blocked the channels at the μM level, while the trans-side addition of SPC did not affect. SPC hardly change the membrane capacitance. A kinetic model held in the SPC effect. SPC could thus exert a specific effect via its binding to the cytoplasmic domain of the RyR molecule. On the other hand, both cis-side and trans-side additions of LPC activated the RyR channels at the μM level. LPC significantly increased the membrane capacitance. No kinetic model held in the LPC effect. Unlike SPC, LPC could thus exert a nonspecific indirect effect on the RyR channel via a fusion of LPC into the membrane lipids." @default.
- W2022204328 created "2016-06-24" @default.
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- W2022204328 date "2010-01-01" @default.
- W2022204328 modified "2023-09-26" @default.
- W2022204328 title "Ryanodine Receptor Channels are Regulated by Specific Binding of A Membrane Phospholipid Metabolite" @default.
- W2022204328 doi "https://doi.org/10.1016/j.bpj.2009.12.1637" @default.
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