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- W2022204458 abstract "We compared CsG and CsA in the DA-to-Lewis rat renal allograft model. At equivalent oral doses, plasma radioimmunoassay (RIA) CsG levels were higher than CsA (P<0.02). Neither drug prevented rejection at doses of 5 mg/kg/day. CsG-treated rats had a higher rejection rate at doses of 7.5 mg/kg/day (P<0.05). Both drugs were equally effective in preventing rejection at doses of 10 mg/kg/day. Neither drug was nephrotoxic at the doses used in this study. CsG is a potent immunosuppressant, and thus a potential clinical successor to CsA. Since CsG and CsA provide equivalent immunosuppression at therapeutic doses, CsG's clinical significance will ultimately depend on its nephrotoxicity in man." @default.
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- W2022204458 date "1987-07-01" @default.
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- W2022204458 title "A COMPARISON OF CYCLOSPORINE A AND Nva2-CYCLOSOPORINE (CYCLOSPORINE G) IN A RAT RENAL ALLOGRAFT MODEL" @default.
- W2022204458 doi "https://doi.org/10.1097/00007890-198707000-00003" @default.
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