FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022204648> ?p ?o ?g. }

• W2022204648 endingPage "1015" @default.
• W2022204648 startingPage "1011" @default.
• W2022204648 abstract "Cardiac muscle contraction is primarily controlled through calcium-dependent interactions among thin filament regulatory proteins. Modulation of the calcium sensitivity of thin filament regulatory proteins is a known pharmacological target for treatment of heart failure. Agents that exert a positive-inotropic effect, by directly acting on thin filament regulatory proteins or on cross-bridge cycling, are commonly referred to as calcium sensitizers [ [1] Endoh M. Mechanism of action of Ca2+; sensitizerss—update 2001. Cardiovasc Drug Ther. 2001; 15: 397-403 Crossref PubMed Scopus (57) Google Scholar ]. The regulatory apparatus of the thin filament is comprised of tropomyosin and a protein complex known as troponin. Troponin is a ternary assembly of proteins composed of troponin C (TnC), troponin I (TnI), and troponin T (TnT). Each troponin subunit has been implicated in a distinct function. TnC is the calcium sensor of the troponin complex responsible for detection of the calcium signal and initiation of muscle contraction. TnI serves to inhibit the myosin–actin interaction in the absence of calcium, while TnT plays a role in transmitting the calcium signal by anchoring the complex to the thin filament. On the thin filament, troponin and tropomyosin confer not only calcium sensitivity to contraction, but modulation by phosphorylation of TnI as well. Both protein kinase A (PKA) and protein kinase C phosphorylation of cardiac TnI are of particular importance in modulating myofilament function and controlling cardiac dynamics [ 2 Burkart E.M. Sumandea M.P. Kobayashi T. Nili M. Martin A.F. Homsher E. et al. Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity. J Biol Chem. 2003; 278: 11265-11272 Crossref PubMed Scopus (136) Google Scholar , 3 Solaro R.J. Burkart E.M. Functional defects in troponin and the systems biology of heart failure. J Mol Cell Cardiol. 2003; 34: 689-693 Abstract Full Text PDF Scopus (17) Google Scholar ]. Thus, agents that target the regulatory apparatus by increasing the calcium sensitivity without deleterious effects on the intracellular calcium concentration or oxygen consumption are useful in the treatment of heart failure. The calcium sensor protein, TnC, is a primary target for development of calcium-sensitizing agents that function by making regulatory thin filament proteins more sensitive to calcium." @default.
• W2022204648 created "2016-06-24" @default.
• W2022204648 creator A5010618981 @default.
• W2022204648 creator A5050068257 @default.
• W2022204648 date "2003-09-01" @default.
• W2022204648 modified "2023-09-27" @default.
• W2022204648 title "Molecular mechanism of levosimendan action: an update" @default.
• W2022204648 cites W1508217034 @default.
• W2022204648 cites W1523578038 @default.
• W2022204648 cites W1550330933 @default.
• W2022204648 cites W1554612821 @default.
• W2022204648 cites W1554913126 @default.
• W2022204648 cites W1555694689 @default.
• W2022204648 cites W1556535974 @default.
• W2022204648 cites W1589403305 @default.
• W2022204648 cites W1951119526 @default.
• W2022204648 cites W1965562904 @default.
• W2022204648 cites W1967671435 @default.
• W2022204648 cites W1968965382 @default.
• W2022204648 cites W1974327668 @default.
• W2022204648 cites W1979547079 @default.
• W2022204648 cites W1984651643 @default.
• W2022204648 cites W1984765095 @default.
• W2022204648 cites W1985345188 @default.
• W2022204648 cites W1990049123 @default.
• W2022204648 cites W1990323401 @default.
• W2022204648 cites W1991564648 @default.
• W2022204648 cites W1992491894 @default.
• W2022204648 cites W2000876750 @default.
• W2022204648 cites W2004189116 @default.
• W2022204648 cites W2005637426 @default.
• W2022204648 cites W2008983501 @default.
• W2022204648 cites W2010178895 @default.
• W2022204648 cites W2011583811 @default.
• W2022204648 cites W2013730193 @default.
• W2022204648 cites W2014534876 @default.
• W2022204648 cites W2015759305 @default.
• W2022204648 cites W2018155990 @default.
• W2022204648 cites W2031294645 @default.
• W2022204648 cites W2034679294 @default.
• W2022204648 cites W2034897679 @default.
• W2022204648 cites W2035320775 @default.
• W2022204648 cites W2044848803 @default.
• W2022204648 cites W2045910367 @default.
• W2022204648 cites W205152666 @default.
• W2022204648 cites W2057472718 @default.
• W2022204648 cites W2058581105 @default.
• W2022204648 cites W2068739543 @default.
• W2022204648 cites W2073883999 @default.
• W2022204648 cites W2078244199 @default.
• W2022204648 cites W2085351556 @default.
• W2022204648 cites W2085560095 @default.
• W2022204648 cites W2089503416 @default.
• W2022204648 cites W2090484202 @default.
• W2022204648 cites W2092372435 @default.
• W2022204648 cites W2093213355 @default.
• W2022204648 cites W2095302365 @default.
• W2022204648 cites W2103019222 @default.
• W2022204648 cites W2113602217 @default.
• W2022204648 cites W2114115913 @default.
• W2022204648 cites W2121651313 @default.
• W2022204648 cites W2130310240 @default.
• W2022204648 cites W2134080121 @default.
• W2022204648 cites W2139565971 @default.
• W2022204648 cites W2141011888 @default.
• W2022204648 cites W2143183688 @default.
• W2022204648 cites W2157566126 @default.
• W2022204648 cites W2282883086 @default.
• W2022204648 cites W2405095488 @default.
• W2022204648 doi "https://doi.org/10.1016/s0022-2828(03)00202-5" @default.
• W2022204648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12967622" @default.
• W2022204648 hasPublicationYear "2003" @default.
• W2022204648 type Work @default.
• W2022204648 sameAs 2022204648 @default.
• W2022204648 citedByCount "13" @default.
• W2022204648 countsByYear W20222046482012 @default.
• W2022204648 countsByYear W20222046482015 @default.
• W2022204648 countsByYear W20222046482019 @default.
• W2022204648 crossrefType "journal-article" @default.
• W2022204648 hasAuthorship W2022204648A5010618981 @default.
• W2022204648 hasAuthorship W2022204648A5050068257 @default.
• W2022204648 hasConcept C105702510 @default.
• W2022204648 hasConcept C115725540 @default.
• W2022204648 hasConcept C12554922 @default.
• W2022204648 hasConcept C125705527 @default.
• W2022204648 hasConcept C126322002 @default.
• W2022204648 hasConcept C174054327 @default.
• W2022204648 hasConcept C185592680 @default.
• W2022204648 hasConcept C205875245 @default.
• W2022204648 hasConcept C2776050358 @default.
• W2022204648 hasConcept C2778996579 @default.
• W2022204648 hasConcept C36036425 @default.
• W2022204648 hasConcept C500558357 @default.
• W2022204648 hasConcept C519063684 @default.
• W2022204648 hasConcept C55493867 @default.
• W2022204648 hasConcept C71924100 @default.
• W2022204648 hasConcept C86803240 @default.
• W2022204648 hasConcept C8880881 @default.

• next