FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022205995> ?p ?o ?g. }

• W2022205995 endingPage "13548" @default.
• W2022205995 startingPage "13543" @default.
• W2022205995 abstract "The x-ray crystal structure of recombinant trichodiene synthase from Fusarium sporotrichioides has been determined to 2.5-Å resolution, both unliganded and complexed with inorganic pyrophosphate. This reaction product coordinates to three Mg 2+ ions near the mouth of the active site cleft. A comparison of the liganded and unliganded structures reveals a ligand-induced conformational change that closes the mouth of the active site cleft. Binding of the substrate farnesyl diphosphate similarly may trigger this conformational change, which would facilitate catalysis by protecting reactive carbocationic intermediates in the cyclization cascade. Trichodiene synthase also shares significant structural similarity with other sesquiterpene synthases despite a lack of significant sequence identity. This similarity indicates divergence from a common ancestor early in the evolution of terpene biosynthesis." @default.
• W2022205995 created "2016-06-24" @default.
• W2022205995 creator A5007669776 @default.
• W2022205995 creator A5015579596 @default.
• W2022205995 creator A5089983022 @default.
• W2022205995 date "2001-11-06" @default.
• W2022205995 modified "2023-10-16" @default.
• W2022205995 title "Structure of trichodiene synthase from <i>Fusarium sporotrichioides</i> provides mechanistic inferences on the terpene cyclization cascade" @default.
• W2022205995 cites W1534973403 @default.
• W2022205995 cites W1539796472 @default.
• W2022205995 cites W1963921910 @default.
• W2022205995 cites W1967231259 @default.
• W2022205995 cites W1971998602 @default.
• W2022205995 cites W1973284372 @default.
• W2022205995 cites W1981624390 @default.
• W2022205995 cites W1987657458 @default.
• W2022205995 cites W1993609768 @default.
• W2022205995 cites W1995017064 @default.
• W2022205995 cites W1997638680 @default.
• W2022205995 cites W1998890447 @default.
• W2022205995 cites W2001641653 @default.
• W2022205995 cites W2006843125 @default.
• W2022205995 cites W2013083986 @default.
• W2022205995 cites W2023533798 @default.
• W2022205995 cites W2027133726 @default.
• W2022205995 cites W2028231353 @default.
• W2022205995 cites W2037203170 @default.
• W2022205995 cites W2041156247 @default.
• W2022205995 cites W2041374535 @default.
• W2022205995 cites W2044082153 @default.
• W2022205995 cites W2051778475 @default.
• W2022205995 cites W2056400844 @default.
• W2022205995 cites W2059330245 @default.
• W2022205995 cites W2062743073 @default.
• W2022205995 cites W2069550304 @default.
• W2022205995 cites W2074025138 @default.
• W2022205995 cites W2074105121 @default.
• W2022205995 cites W2078248419 @default.
• W2022205995 cites W2080690387 @default.
• W2022205995 cites W2091078202 @default.
• W2022205995 cites W2106315897 @default.
• W2022205995 cites W2131124255 @default.
• W2022205995 cites W2152326664 @default.
• W2022205995 cites W2953222385 @default.
• W2022205995 cites W4241517981 @default.
• W2022205995 cites W4253258361 @default.
• W2022205995 cites W942848743 @default.
• W2022205995 doi "https://doi.org/10.1073/pnas.231313098" @default.
• W2022205995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/61077" @default.
• W2022205995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11698643" @default.
• W2022205995 hasPublicationYear "2001" @default.
• W2022205995 type Work @default.
• W2022205995 sameAs 2022205995 @default.
• W2022205995 citedByCount "237" @default.
• W2022205995 countsByYear W20222059952012 @default.
• W2022205995 countsByYear W20222059952013 @default.
• W2022205995 countsByYear W20222059952014 @default.
• W2022205995 countsByYear W20222059952015 @default.
• W2022205995 countsByYear W20222059952016 @default.
• W2022205995 countsByYear W20222059952017 @default.
• W2022205995 countsByYear W20222059952018 @default.
• W2022205995 countsByYear W20222059952019 @default.
• W2022205995 countsByYear W20222059952020 @default.
• W2022205995 countsByYear W20222059952021 @default.
• W2022205995 countsByYear W20222059952022 @default.
• W2022205995 countsByYear W20222059952023 @default.
• W2022205995 crossrefType "journal-article" @default.
• W2022205995 hasAuthorship W2022205995A5007669776 @default.
• W2022205995 hasAuthorship W2022205995A5015579596 @default.
• W2022205995 hasAuthorship W2022205995A5089983022 @default.
• W2022205995 hasBestOaLocation W20222059952 @default.
• W2022205995 hasConcept C107824862 @default.
• W2022205995 hasConcept C112243037 @default.
• W2022205995 hasConcept C116569031 @default.
• W2022205995 hasConcept C139489369 @default.
• W2022205995 hasConcept C170493617 @default.
• W2022205995 hasConcept C181199279 @default.
• W2022205995 hasConcept C185592680 @default.
• W2022205995 hasConcept C2776990775 @default.
• W2022205995 hasConcept C41183919 @default.
• W2022205995 hasConcept C44937612 @default.
• W2022205995 hasConcept C553450214 @default.
• W2022205995 hasConcept C55493867 @default.
• W2022205995 hasConcept C71240020 @default.
• W2022205995 hasConceptScore W2022205995C107824862 @default.
• W2022205995 hasConceptScore W2022205995C112243037 @default.
• W2022205995 hasConceptScore W2022205995C116569031 @default.
• W2022205995 hasConceptScore W2022205995C139489369 @default.
• W2022205995 hasConceptScore W2022205995C170493617 @default.
• W2022205995 hasConceptScore W2022205995C181199279 @default.
• W2022205995 hasConceptScore W2022205995C185592680 @default.
• W2022205995 hasConceptScore W2022205995C2776990775 @default.
• W2022205995 hasConceptScore W2022205995C41183919 @default.
• W2022205995 hasConceptScore W2022205995C44937612 @default.
• W2022205995 hasConceptScore W2022205995C553450214 @default.
• W2022205995 hasConceptScore W2022205995C55493867 @default.
• W2022205995 hasConceptScore W2022205995C71240020 @default.
• W2022205995 hasIssue "24" @default.

• next