Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022207041> ?p ?o ?g. }
- W2022207041 abstract "Two-dimensional crystals of protein kinase C (PKC) delta, its regulatory domain (RDdelta), and the enzyme complexed with the substrate myelin basic protein have been grown on lipid monolayers composed of phosphatidylcholine: phosphatidylserine: diolein (45:50:5, molar ratio). Images have been reconstructed to 10-A resolution. The unit cells of all three proteins have cell edges a = b and interedge angle gamma = 60 degrees. RDdelta has an edge length of 33 +/- 1 A, and its reconstruction is donut shaped. The three-dimensional reconstructions from the PKCdelta C1b crystal structure () can be accommodated in this two-dimensional projection. Intact PKCdelta has an edge length of 46 +/- 1 A in the presence or absence of a nonhydrolyzable ATP analog, AMP-PnP. Its reconstruction has a similar donut shape, which can accommodate the C1b domain, but the spacing between donuts is greater than that in RDdelta; some additional structure is visible between the donuts. The complex of PKCdelta and myelin basic protein, with or without AMP-PnP, has an edge length of 43 +/- 1 A and a distinct structure. These results indicate that the C1 domains of RDdelta are tightly packed in the plane of the membrane in the two-dimensional crystals, that there is a single molecule of PKCdelta in the unit cell, and that its interaction with myelin basic protein induces a shift in conformation and/or packing of the enzyme." @default.
- W2022207041 created "2016-06-24" @default.
- W2022207041 creator A5000432971 @default.
- W2022207041 creator A5035694899 @default.
- W2022207041 creator A5052350243 @default.
- W2022207041 creator A5084650322 @default.
- W2022207041 date "2002-05-01" @default.
- W2022207041 modified "2023-09-29" @default.
- W2022207041 title "Two-Dimensional Crystal Structures of Protein Kinase C-δ, Its Regulatory Domain, and the Enzyme Complexed with Myelin Basic Protein" @default.
- W2022207041 cites W1555145232 @default.
- W2022207041 cites W1562879925 @default.
- W2022207041 cites W1933897045 @default.
- W2022207041 cites W1965581896 @default.
- W2022207041 cites W1967689256 @default.
- W2022207041 cites W1989492758 @default.
- W2022207041 cites W1990869436 @default.
- W2022207041 cites W1991317030 @default.
- W2022207041 cites W1995861681 @default.
- W2022207041 cites W1996204565 @default.
- W2022207041 cites W1997354932 @default.
- W2022207041 cites W2000224326 @default.
- W2022207041 cites W2005593816 @default.
- W2022207041 cites W2010994547 @default.
- W2022207041 cites W2012861970 @default.
- W2022207041 cites W2012940653 @default.
- W2022207041 cites W2016533183 @default.
- W2022207041 cites W2017797223 @default.
- W2022207041 cites W2033430541 @default.
- W2022207041 cites W2035840997 @default.
- W2022207041 cites W2038721272 @default.
- W2022207041 cites W2042055643 @default.
- W2022207041 cites W2043617365 @default.
- W2022207041 cites W2048116173 @default.
- W2022207041 cites W2048982317 @default.
- W2022207041 cites W2052266365 @default.
- W2022207041 cites W2052578867 @default.
- W2022207041 cites W2053769279 @default.
- W2022207041 cites W2054984970 @default.
- W2022207041 cites W2056713455 @default.
- W2022207041 cites W2059130480 @default.
- W2022207041 cites W2061365022 @default.
- W2022207041 cites W2067405360 @default.
- W2022207041 cites W2072360439 @default.
- W2022207041 cites W2075889486 @default.
- W2022207041 cites W2076774195 @default.
- W2022207041 cites W2091673674 @default.
- W2022207041 cites W2093650342 @default.
- W2022207041 cites W2097331211 @default.
- W2022207041 cites W2104969843 @default.
- W2022207041 cites W2137882621 @default.
- W2022207041 cites W2137986798 @default.
- W2022207041 cites W2149705812 @default.
- W2022207041 cites W2160341948 @default.
- W2022207041 cites W2165102205 @default.
- W2022207041 cites W2400884176 @default.
- W2022207041 cites W4234251892 @default.
- W2022207041 cites W97508067 @default.
- W2022207041 doi "https://doi.org/10.1016/s0006-3495(02)75611-7" @default.
- W2022207041 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1302058" @default.
- W2022207041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11964256" @default.
- W2022207041 hasPublicationYear "2002" @default.
- W2022207041 type Work @default.
- W2022207041 sameAs 2022207041 @default.
- W2022207041 citedByCount "7" @default.
- W2022207041 countsByYear W20222070412014 @default.
- W2022207041 crossrefType "journal-article" @default.
- W2022207041 hasAuthorship W2022207041A5000432971 @default.
- W2022207041 hasAuthorship W2022207041A5035694899 @default.
- W2022207041 hasAuthorship W2022207041A5052350243 @default.
- W2022207041 hasAuthorship W2022207041A5084650322 @default.
- W2022207041 hasBestOaLocation W20222070411 @default.
- W2022207041 hasConcept C12554922 @default.
- W2022207041 hasConcept C169760540 @default.
- W2022207041 hasConcept C181199279 @default.
- W2022207041 hasConcept C185592680 @default.
- W2022207041 hasConcept C195794163 @default.
- W2022207041 hasConcept C2778609137 @default.
- W2022207041 hasConcept C2780876595 @default.
- W2022207041 hasConcept C529278444 @default.
- W2022207041 hasConcept C55493867 @default.
- W2022207041 hasConcept C71240020 @default.
- W2022207041 hasConcept C8010536 @default.
- W2022207041 hasConcept C86803240 @default.
- W2022207041 hasConcept C97029542 @default.
- W2022207041 hasConceptScore W2022207041C12554922 @default.
- W2022207041 hasConceptScore W2022207041C169760540 @default.
- W2022207041 hasConceptScore W2022207041C181199279 @default.
- W2022207041 hasConceptScore W2022207041C185592680 @default.
- W2022207041 hasConceptScore W2022207041C195794163 @default.
- W2022207041 hasConceptScore W2022207041C2778609137 @default.
- W2022207041 hasConceptScore W2022207041C2780876595 @default.
- W2022207041 hasConceptScore W2022207041C529278444 @default.
- W2022207041 hasConceptScore W2022207041C55493867 @default.
- W2022207041 hasConceptScore W2022207041C71240020 @default.
- W2022207041 hasConceptScore W2022207041C8010536 @default.
- W2022207041 hasConceptScore W2022207041C86803240 @default.
- W2022207041 hasConceptScore W2022207041C97029542 @default.
- W2022207041 hasLocation W20222070411 @default.
- W2022207041 hasLocation W20222070412 @default.
- W2022207041 hasLocation W20222070413 @default.