FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022207967> ?p ?o ?g. }

• W2022207967 endingPage "442" @default.
• W2022207967 startingPage "437" @default.
• W2022207967 abstract "ADAMs (A disintegrin and metalloproteinase) are a recently discovered family of proteins with significant primary sequence similarity to the reprolysin family of snake venomases. These ADAMs closest known homologues are the type III reprolysin enzymes which have been demonstrated to be, among other things potent type IV collagenases. ADAMs are putative membrane linked proteins with several domains including a metalloproteinase domain, a potential integrin binding domain, a cysteine rich sequence and an EGF like sequence. They have been implicated in a wide variety of functions including basement membrane degradation and cell-cell and cell-matrix interactions. We have used RT-PCR and Northern blotting to characterise the expression of members of this family in cells derived from a variety of haematological malignancies including leukaemia (HL60 and Jurkat), erythroleukaemia (K562), lymphoma (U937 and Cupillo) and myeloma (U266B1). We find clear expression of four members of this novel family of proteins but note differences in the expression levels of each member. The ADAMs known as MADM (ADAM10), MCMP (ADAM12, MDC9) and Metargidin (ADAM15) which all possess potentially active metalloproteinase domains are expressed in all these cell types to significant levels. The putative tumour suppressor gene MDC (ADAM11) is expressed at very low levels in all cells examined. As ADAMs may have both potential metalloproteinase activity and adhesive domains we wish to explore the role of these proteins with regard to pathophysiology of haematological malignancy such as egression of leukaemic cells from the bone marrow." @default.
• W2022207967 created "2016-06-24" @default.
• W2022207967 creator A5024939054 @default.
• W2022207967 creator A5070309078 @default.
• W2022207967 creator A5083996892 @default.
• W2022207967 date "1997-06-01" @default.
• W2022207967 modified "2023-10-06" @default.
• W2022207967 title "Expression of Members of the Novel Membrane Linked Metalloproteinase Family ADAM in Cells Derived from a Range of Haematological Malignancies" @default.
• W2022207967 cites W1592121394 @default.
• W2022207967 cites W1775873926 @default.
• W2022207967 cites W1782613870 @default.
• W2022207967 cites W1894541755 @default.
• W2022207967 cites W193139673 @default.
• W2022207967 cites W1964849541 @default.
• W2022207967 cites W1968902070 @default.
• W2022207967 cites W1977127210 @default.
• W2022207967 cites W1979390430 @default.
• W2022207967 cites W1983219998 @default.
• W2022207967 cites W1983995459 @default.
• W2022207967 cites W1984064042 @default.
• W2022207967 cites W1989228411 @default.
• W2022207967 cites W1992269344 @default.
• W2022207967 cites W2012844494 @default.
• W2022207967 cites W2013741645 @default.
• W2022207967 cites W2020349375 @default.
• W2022207967 cites W2026151657 @default.
• W2022207967 cites W2041233605 @default.
• W2022207967 cites W2042142377 @default.
• W2022207967 cites W2054881604 @default.
• W2022207967 cites W2062784484 @default.
• W2022207967 cites W2072011504 @default.
• W2022207967 cites W2074442731 @default.
• W2022207967 cites W2095498651 @default.
• W2022207967 cites W2096589296 @default.
• W2022207967 cites W2109625553 @default.
• W2022207967 cites W2109658199 @default.
• W2022207967 cites W2141972226 @default.
• W2022207967 cites W2143996326 @default.
• W2022207967 cites W2158198055 @default.
• W2022207967 cites W2159692814 @default.
• W2022207967 cites W2186648986 @default.
• W2022207967 cites W2223049042 @default.
• W2022207967 cites W2332032575 @default.
• W2022207967 cites W2396442732 @default.
• W2022207967 cites W28646162 @default.
• W2022207967 cites W4237063914 @default.
• W2022207967 doi "https://doi.org/10.1006/bbrc.1997.6714" @default.
• W2022207967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9199213" @default.
• W2022207967 hasPublicationYear "1997" @default.
• W2022207967 type Work @default.
• W2022207967 sameAs 2022207967 @default.
• W2022207967 citedByCount "101" @default.
• W2022207967 countsByYear W20222079672012 @default.
• W2022207967 countsByYear W20222079672013 @default.
• W2022207967 countsByYear W20222079672014 @default.
• W2022207967 countsByYear W20222079672015 @default.
• W2022207967 countsByYear W20222079672016 @default.
• W2022207967 countsByYear W20222079672017 @default.
• W2022207967 countsByYear W20222079672018 @default.
• W2022207967 countsByYear W20222079672019 @default.
• W2022207967 countsByYear W20222079672020 @default.
• W2022207967 countsByYear W20222079672023 @default.
• W2022207967 crossrefType "journal-article" @default.
• W2022207967 hasAuthorship W2022207967A5024939054 @default.
• W2022207967 hasAuthorship W2022207967A5070309078 @default.
• W2022207967 hasAuthorship W2022207967A5083996892 @default.
• W2022207967 hasConcept C109523444 @default.
• W2022207967 hasConcept C153911025 @default.
• W2022207967 hasConcept C171122931 @default.
• W2022207967 hasConcept C179464577 @default.
• W2022207967 hasConcept C2776090121 @default.
• W2022207967 hasConcept C2778259572 @default.
• W2022207967 hasConcept C2778715156 @default.
• W2022207967 hasConcept C502942594 @default.
• W2022207967 hasConcept C54355233 @default.
• W2022207967 hasConcept C55728118 @default.
• W2022207967 hasConcept C81885089 @default.
• W2022207967 hasConcept C86803240 @default.
• W2022207967 hasConcept C8891405 @default.
• W2022207967 hasConcept C95444343 @default.
• W2022207967 hasConceptScore W2022207967C109523444 @default.
• W2022207967 hasConceptScore W2022207967C153911025 @default.
• W2022207967 hasConceptScore W2022207967C171122931 @default.
• W2022207967 hasConceptScore W2022207967C179464577 @default.
• W2022207967 hasConceptScore W2022207967C2776090121 @default.
• W2022207967 hasConceptScore W2022207967C2778259572 @default.
• W2022207967 hasConceptScore W2022207967C2778715156 @default.
• W2022207967 hasConceptScore W2022207967C502942594 @default.
• W2022207967 hasConceptScore W2022207967C54355233 @default.
• W2022207967 hasConceptScore W2022207967C55728118 @default.
• W2022207967 hasConceptScore W2022207967C81885089 @default.
• W2022207967 hasConceptScore W2022207967C86803240 @default.
• W2022207967 hasConceptScore W2022207967C8891405 @default.
• W2022207967 hasConceptScore W2022207967C95444343 @default.
• W2022207967 hasIssue "2" @default.
• W2022207967 hasLocation W20222079671 @default.
• W2022207967 hasLocation W20222079672 @default.
• W2022207967 hasOpenAccess W2022207967 @default.

• next