FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022207968> ?p ?o ?g. }

• W2022207968 endingPage "14" @default.
• W2022207968 startingPage "1" @default.
• W2022207968 abstract "Substantial evidence implicates -amyloid (A) peptides in the etiology of Alzheimer’s disease (AD). A is produced by the proteolytic cleavage of the amyloid precursor protein by - and -secretase suggesting that -secretase inhibition may provide therapeutic benefit for AD. Although many -secretase inhibitors have been shown to be potent at lowering A, some have also been shown to have side effects following repeated administration. All of these side effects can be attributed to altered Notch signaling, another -secretase substrate. Here we describe the in vivo characterization of the novel -secretase inhibitor SCH 697466 in rodents. Although SCH 697466 was effective at lowering A, Notch-related side effects in the intestine and thymus were observed following subchronic administration at doses that provided sustained and complete lowering of A. However, additional studies revealed that both partial but sustained lowering of Aand complete but less sustained lowering of A were successful approaches for managing Notch-related side effects. Further, changes in several Notch-related biomarkers paralleled the side effect observations. Taken together, these studies demonstrated that, by carefully varying the extent and duration of A lowering by -secretase inhibitors, it is possible to obtain robust and sustained lowering of A without evidence of Notch-related side effects." @default.
• W2022207968 created "2016-06-24" @default.
• W2022207968 creator A5000432967 @default.
• W2022207968 creator A5010738468 @default.
• W2022207968 creator A5012500148 @default.
• W2022207968 creator A5016350680 @default.
• W2022207968 creator A5018721125 @default.
• W2022207968 creator A5022458239 @default.
• W2022207968 creator A5026984704 @default.
• W2022207968 creator A5027303286 @default.
• W2022207968 creator A5036966448 @default.
• W2022207968 creator A5044736370 @default.
• W2022207968 creator A5050737001 @default.
• W2022207968 creator A5053889270 @default.
• W2022207968 creator A5061970074 @default.
• W2022207968 creator A5069126678 @default.
• W2022207968 creator A5072171783 @default.
• W2022207968 creator A5082587334 @default.
• W2022207968 creator A5085153253 @default.
• W2022207968 creator A5086140940 @default.
• W2022207968 date "2013-01-01" @default.
• W2022207968 modified "2023-09-22" @default.
• W2022207968 title "In Vivo Characterization of a Novel -Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects" @default.
• W2022207968 cites W139300322 @default.
• W2022207968 cites W1568038787 @default.
• W2022207968 cites W1578578139 @default.
• W2022207968 cites W1675105744 @default.
• W2022207968 cites W188237391 @default.
• W2022207968 cites W1979466033 @default.
• W2022207968 cites W1989654750 @default.
• W2022207968 cites W1993428183 @default.
• W2022207968 cites W2013843163 @default.
• W2022207968 cites W2016193774 @default.
• W2022207968 cites W2036288989 @default.
• W2022207968 cites W2042082068 @default.
• W2022207968 cites W2061154091 @default.
• W2022207968 cites W2065706231 @default.
• W2022207968 cites W2068660068 @default.
• W2022207968 cites W2071806349 @default.
• W2022207968 cites W2072996585 @default.
• W2022207968 cites W2081471404 @default.
• W2022207968 cites W2083304655 @default.
• W2022207968 cites W2093317186 @default.
• W2022207968 cites W2096410114 @default.
• W2022207968 cites W2097705657 @default.
• W2022207968 cites W2103440561 @default.
• W2022207968 cites W2112628891 @default.
• W2022207968 cites W2113589784 @default.
• W2022207968 cites W2117618489 @default.
• W2022207968 cites W2122575473 @default.
• W2022207968 cites W2126995971 @default.
• W2022207968 cites W2130765686 @default.
• W2022207968 cites W2133962760 @default.
• W2022207968 cites W2143024384 @default.
• W2022207968 cites W2152827927 @default.
• W2022207968 cites W2153747061 @default.
• W2022207968 cites W2154144191 @default.
• W2022207968 cites W2154861644 @default.
• W2022207968 cites W2163185773 @default.
• W2022207968 cites W2167864502 @default.
• W2022207968 cites W2168286036 @default.
• W2022207968 cites W2172066391 @default.
• W2022207968 cites W2263938816 @default.
• W2022207968 cites W2328959904 @default.
• W2022207968 cites W2412568181 @default.
• W2022207968 doi "https://doi.org/10.1155/2013/823528" @default.
• W2022207968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3612465" @default.
• W2022207968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23573456" @default.
• W2022207968 hasPublicationYear "2013" @default.
• W2022207968 type Work @default.
• W2022207968 sameAs 2022207968 @default.
• W2022207968 citedByCount "3" @default.
• W2022207968 countsByYear W20222079682014 @default.
• W2022207968 countsByYear W20222079682017 @default.
• W2022207968 countsByYear W20222079682021 @default.
• W2022207968 crossrefType "journal-article" @default.
• W2022207968 hasAuthorship W2022207968A5000432967 @default.
• W2022207968 hasAuthorship W2022207968A5010738468 @default.
• W2022207968 hasAuthorship W2022207968A5012500148 @default.
• W2022207968 hasAuthorship W2022207968A5016350680 @default.
• W2022207968 hasAuthorship W2022207968A5018721125 @default.
• W2022207968 hasAuthorship W2022207968A5022458239 @default.
• W2022207968 hasAuthorship W2022207968A5026984704 @default.
• W2022207968 hasAuthorship W2022207968A5027303286 @default.
• W2022207968 hasAuthorship W2022207968A5036966448 @default.
• W2022207968 hasAuthorship W2022207968A5044736370 @default.
• W2022207968 hasAuthorship W2022207968A5050737001 @default.
• W2022207968 hasAuthorship W2022207968A5053889270 @default.
• W2022207968 hasAuthorship W2022207968A5061970074 @default.
• W2022207968 hasAuthorship W2022207968A5069126678 @default.
• W2022207968 hasAuthorship W2022207968A5072171783 @default.
• W2022207968 hasAuthorship W2022207968A5082587334 @default.
• W2022207968 hasAuthorship W2022207968A5085153253 @default.
• W2022207968 hasAuthorship W2022207968A5086140940 @default.
• W2022207968 hasBestOaLocation W20222079681 @default.
• W2022207968 hasConcept C126322002 @default.
• W2022207968 hasConcept C142724271 @default.
• W2022207968 hasConcept C161879069 @default.

• next