Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022208233> ?p ?o ?g. }
- W2022208233 endingPage "324" @default.
- W2022208233 startingPage "315" @default.
- W2022208233 abstract "Filamentous fungi are industrially important organisms because of their ability to produce secondary metabolites, and as expression systems for heterologous proteins. Since secretion of secondary metabolites in filamentous fungi is associated with the older, more vacuolated parts of the hyphae culture morphology is a crucial reflection of their physiology in submerged cultures. Therefore, any factor affecting fungal morphology will in turn affect secondary metabolite production. In this study we examine and report the effects of elevated levels of the potent morphogen, carbon dioxide upon morphology and antibiotic production in an industrially important fungal system. The effects of elevated CO2 levels on cephalosporin C (CPC) production, metabolic performance and morphological changes in batch cultures of Acremonium chrysogenum (ATCC 48272) were investigated. High levels of dCO2 led to reduction of CPC production by up to 36%. Both metabolic activity and substrate uptake were severely inhibited by elevated CO2, especially at 15 and 20% CO2. Both micro and macromorphology of A. chrysogenum were profoundly changed in bioprocesses sparged with CO2 especially at high levels, and these changes were a contributory cause of the reduction in CPC production." @default.
- W2022208233 created "2016-06-24" @default.
- W2022208233 creator A5054447652 @default.
- W2022208233 creator A5065336019 @default.
- W2022208233 creator A5067494892 @default.
- W2022208233 date "2008-03-01" @default.
- W2022208233 modified "2023-10-18" @default.
- W2022208233 title "Effects of dissolved carbon dioxide on growth, nutrient consumption, cephalosporin C synthesis and morphology of Acremonium chrysogenum in batch cultures" @default.
- W2022208233 cites W1537627033 @default.
- W2022208233 cites W171932459 @default.
- W2022208233 cites W1963862405 @default.
- W2022208233 cites W1967627034 @default.
- W2022208233 cites W1968834637 @default.
- W2022208233 cites W1975365740 @default.
- W2022208233 cites W1975736007 @default.
- W2022208233 cites W1976133773 @default.
- W2022208233 cites W1976453205 @default.
- W2022208233 cites W1976917368 @default.
- W2022208233 cites W1977468769 @default.
- W2022208233 cites W1982224868 @default.
- W2022208233 cites W1984282107 @default.
- W2022208233 cites W1984878339 @default.
- W2022208233 cites W1987746926 @default.
- W2022208233 cites W1987921645 @default.
- W2022208233 cites W1989957134 @default.
- W2022208233 cites W2003555096 @default.
- W2022208233 cites W2011014253 @default.
- W2022208233 cites W2013898484 @default.
- W2022208233 cites W2015337093 @default.
- W2022208233 cites W2015566489 @default.
- W2022208233 cites W2015678277 @default.
- W2022208233 cites W2019137903 @default.
- W2022208233 cites W2020243397 @default.
- W2022208233 cites W2029275707 @default.
- W2022208233 cites W2029856097 @default.
- W2022208233 cites W2034984143 @default.
- W2022208233 cites W2035246963 @default.
- W2022208233 cites W2038455569 @default.
- W2022208233 cites W2039920401 @default.
- W2022208233 cites W2041265342 @default.
- W2022208233 cites W2041989206 @default.
- W2022208233 cites W2043284948 @default.
- W2022208233 cites W2049964985 @default.
- W2022208233 cites W205091103 @default.
- W2022208233 cites W2062059013 @default.
- W2022208233 cites W2068864876 @default.
- W2022208233 cites W2068966798 @default.
- W2022208233 cites W2069459922 @default.
- W2022208233 cites W2072860772 @default.
- W2022208233 cites W2076815759 @default.
- W2022208233 cites W2077552013 @default.
- W2022208233 cites W2085130155 @default.
- W2022208233 cites W2086413384 @default.
- W2022208233 cites W2086482414 @default.
- W2022208233 cites W2087051547 @default.
- W2022208233 cites W2089035362 @default.
- W2022208233 cites W2091140741 @default.
- W2022208233 cites W2093999433 @default.
- W2022208233 cites W2094358296 @default.
- W2022208233 cites W2094812354 @default.
- W2022208233 cites W2099653663 @default.
- W2022208233 cites W2106951075 @default.
- W2022208233 cites W2108095780 @default.
- W2022208233 cites W2112772095 @default.
- W2022208233 cites W2117979145 @default.
- W2022208233 cites W2128103767 @default.
- W2022208233 cites W2129779495 @default.
- W2022208233 cites W2147172059 @default.
- W2022208233 cites W2154343447 @default.
- W2022208233 cites W2161871739 @default.
- W2022208233 cites W2166649349 @default.
- W2022208233 cites W2325917155 @default.
- W2022208233 cites W4247502853 @default.
- W2022208233 doi "https://doi.org/10.1016/j.enzmictec.2007.10.012" @default.
- W2022208233 hasPublicationYear "2008" @default.
- W2022208233 type Work @default.
- W2022208233 sameAs 2022208233 @default.
- W2022208233 citedByCount "18" @default.
- W2022208233 countsByYear W20222082332012 @default.
- W2022208233 countsByYear W20222082332013 @default.
- W2022208233 countsByYear W20222082332014 @default.
- W2022208233 countsByYear W20222082332015 @default.
- W2022208233 countsByYear W20222082332018 @default.
- W2022208233 countsByYear W20222082332019 @default.
- W2022208233 countsByYear W20222082332021 @default.
- W2022208233 countsByYear W20222082332022 @default.
- W2022208233 crossrefType "journal-article" @default.
- W2022208233 hasAuthorship W2022208233A5054447652 @default.
- W2022208233 hasAuthorship W2022208233A5065336019 @default.
- W2022208233 hasAuthorship W2022208233A5067494892 @default.
- W2022208233 hasConcept C104317684 @default.
- W2022208233 hasConcept C18903297 @default.
- W2022208233 hasConcept C2776067932 @default.
- W2022208233 hasConcept C2777347573 @default.
- W2022208233 hasConcept C2779344128 @default.
- W2022208233 hasConcept C31903555 @default.
- W2022208233 hasConcept C501593827 @default.
- W2022208233 hasConcept C530467964 @default.