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- W2022209595 abstract "ABSTRACT We present, for the first time an in vivo implementation of dynamic light scattering (DLS) adapted to optical coherence tomography (OCT). Human bladder carcinoma tumors were gr own in dorsal skin-fold window chambers fitted to male nude mice and imaged at a rate of 200 Hz using OCT. Maps of speckle decorrelation times (DT) were generated for regions of skin from individual mice as well as for regions containing tumor tissue before and after treatment with chemotherapy. Variations in DT were found between individua l mice exhibiting different skin anatomy (primarily due to deterioration from the window chamber implantation). A significant difference in DT was also observed between tumor regions and surrounding normal tissue. Finally, maps of DT generated for tumor tissue treated with chemotherapy indicated a drop in DT at 24 and 48 hours after treatment. These preliminary results suggest the feasibility of using DLS-OCT to measure intracellular motion as an endogenous contrast mechanism in vivo . Keywords: cell death, apoptosis, dynamic light scattering, optical coherence tomography, speckle decorrelation, window chamber model, treatment monitoring." @default.
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- W2022209595 date "2012-02-09" @default.
- W2022209595 modified "2023-09-23" @default.
- W2022209595 title "Measuring intracellular motion using dynamic light scattering with optical coherence tomography in a mouse tumor model" @default.
- W2022209595 doi "https://doi.org/10.1117/12.908536" @default.
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