Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022209828> ?p ?o ?g. }
- W2022209828 endingPage "381" @default.
- W2022209828 startingPage "374" @default.
- W2022209828 abstract "Maternal virus infection or maternal polyinosinic-polycytidilic acid injection confers behavioral alterations including deficit in prepulse inhibition on the offspring. We previously found delayed myelination specifically in the early postnatal hippocampus in the polyinosinic–polycytidilic acid-injection model. To test whether the transient delay in myelination in the juvenile hippocampus leads to abnormal behaviors after adolescence, we injected lysophosphatidylcholine, a potent demyelinating agent, into the ventral hippocampus of the 10-day-old rat. The lysophosphatidylcholine treatment yielded hypomyelination at postnatal day 16, but myelination reverted to normal level in the adult rat. Neuronal arrays and morphology were not disturbed in this model. We then performed a battery of behavioral tests on the lysophosphatidylcholine-treated and control PBS-injected rats. The lysophosphatidylcholine-treated rats showed deficit in prepulse inhibition, motor hyperactivity in response to methamphetamine and anxiety-related behaviors, all of which are typical behaviors observed in the maternal infection models. These findings suggest that the timing of myelination in the early postnatal hippocampus is crucial for the proper development of sensorimotor and emotional functions. The lysophosphatidylcholine-treated rat without a gross anatomical defect is useful as a model for psychotic disorders." @default.
- W2022209828 created "2016-06-24" @default.
- W2022209828 creator A5012893729 @default.
- W2022209828 creator A5019563298 @default.
- W2022209828 creator A5025645497 @default.
- W2022209828 creator A5026251829 @default.
- W2022209828 creator A5060054989 @default.
- W2022209828 creator A5063479633 @default.
- W2022209828 creator A5078950643 @default.
- W2022209828 creator A5084080520 @default.
- W2022209828 date "2008-12-01" @default.
- W2022209828 modified "2023-09-24" @default.
- W2022209828 title "Lysophosphatidylcholine induces delayed myelination in the juvenile ventral hippocampus and behavioral alterations in adulthood" @default.
- W2022209828 cites W1916247363 @default.
- W2022209828 cites W1966407955 @default.
- W2022209828 cites W1966465143 @default.
- W2022209828 cites W1975996377 @default.
- W2022209828 cites W1981466732 @default.
- W2022209828 cites W1983239397 @default.
- W2022209828 cites W1984891852 @default.
- W2022209828 cites W1991177440 @default.
- W2022209828 cites W1999319868 @default.
- W2022209828 cites W2000268407 @default.
- W2022209828 cites W2005432794 @default.
- W2022209828 cites W2011937563 @default.
- W2022209828 cites W2021794959 @default.
- W2022209828 cites W2031337229 @default.
- W2022209828 cites W2033880528 @default.
- W2022209828 cites W2036180008 @default.
- W2022209828 cites W2037538259 @default.
- W2022209828 cites W2041812587 @default.
- W2022209828 cites W2045492160 @default.
- W2022209828 cites W2046783872 @default.
- W2022209828 cites W2050179923 @default.
- W2022209828 cites W2059337036 @default.
- W2022209828 cites W2081988042 @default.
- W2022209828 cites W2103425524 @default.
- W2022209828 cites W2113207193 @default.
- W2022209828 cites W2116329496 @default.
- W2022209828 cites W2117927049 @default.
- W2022209828 cites W2120869510 @default.
- W2022209828 cites W2124667416 @default.
- W2022209828 cites W2125244470 @default.
- W2022209828 cites W2127454740 @default.
- W2022209828 cites W2139961441 @default.
- W2022209828 cites W2143217444 @default.
- W2022209828 cites W2144083595 @default.
- W2022209828 cites W2145533845 @default.
- W2022209828 cites W2158527872 @default.
- W2022209828 doi "https://doi.org/10.1016/j.neuint.2008.09.009" @default.
- W2022209828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18930092" @default.
- W2022209828 hasPublicationYear "2008" @default.
- W2022209828 type Work @default.
- W2022209828 sameAs 2022209828 @default.
- W2022209828 citedByCount "11" @default.
- W2022209828 countsByYear W20222098282012 @default.
- W2022209828 countsByYear W20222098282016 @default.
- W2022209828 countsByYear W20222098282017 @default.
- W2022209828 countsByYear W20222098282020 @default.
- W2022209828 countsByYear W20222098282021 @default.
- W2022209828 crossrefType "journal-article" @default.
- W2022209828 hasAuthorship W2022209828A5012893729 @default.
- W2022209828 hasAuthorship W2022209828A5019563298 @default.
- W2022209828 hasAuthorship W2022209828A5025645497 @default.
- W2022209828 hasAuthorship W2022209828A5026251829 @default.
- W2022209828 hasAuthorship W2022209828A5060054989 @default.
- W2022209828 hasAuthorship W2022209828A5063479633 @default.
- W2022209828 hasAuthorship W2022209828A5078950643 @default.
- W2022209828 hasAuthorship W2022209828A5084080520 @default.
- W2022209828 hasConcept C112672928 @default.
- W2022209828 hasConcept C118552586 @default.
- W2022209828 hasConcept C126322002 @default.
- W2022209828 hasConcept C134018914 @default.
- W2022209828 hasConcept C141421786 @default.
- W2022209828 hasConcept C15744967 @default.
- W2022209828 hasConcept C169760540 @default.
- W2022209828 hasConcept C2776330855 @default.
- W2022209828 hasConcept C2776412080 @default.
- W2022209828 hasConcept C2778596009 @default.
- W2022209828 hasConcept C2778918659 @default.
- W2022209828 hasConcept C2779234561 @default.
- W2022209828 hasConcept C2781161787 @default.
- W2022209828 hasConcept C41625074 @default.
- W2022209828 hasConcept C54355233 @default.
- W2022209828 hasConcept C71924100 @default.
- W2022209828 hasConcept C86803240 @default.
- W2022209828 hasConceptScore W2022209828C112672928 @default.
- W2022209828 hasConceptScore W2022209828C118552586 @default.
- W2022209828 hasConceptScore W2022209828C126322002 @default.
- W2022209828 hasConceptScore W2022209828C134018914 @default.
- W2022209828 hasConceptScore W2022209828C141421786 @default.
- W2022209828 hasConceptScore W2022209828C15744967 @default.
- W2022209828 hasConceptScore W2022209828C169760540 @default.
- W2022209828 hasConceptScore W2022209828C2776330855 @default.
- W2022209828 hasConceptScore W2022209828C2776412080 @default.
- W2022209828 hasConceptScore W2022209828C2778596009 @default.
- W2022209828 hasConceptScore W2022209828C2778918659 @default.
- W2022209828 hasConceptScore W2022209828C2779234561 @default.