Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022211087> ?p ?o ?g. }
- W2022211087 abstract "Background Growth hormone–releasing hormone agonists ( GHRH ‐As) stimulate cardiac repair following myocardial infarction ( MI ) in rats through the activation of the GHRH signaling pathway within the heart. We tested the hypothesis that the administration of GHRH ‐As prevents ventricular remodeling in a swine subacute MI model. Methods and Results Twelve female Yorkshire swine (25 to 30 kg) underwent transient occlusion of the left anterior descending coronary artery ( MI ). Two weeks post MI , swine were randomized to receive injections of either 30 μg/kg GHRH ‐A ( MR ‐409) ( GHRH ‐A group; n=6) or vehicle (placebo group; n=6). Cardiac magnetic resonance imaging and pressure–volume loops were obtained at multiple time points. Infarct, border, and remote (noninfarcted) zones were assessed for GHRH receptor by immunohistochemistry. Four weeks of GHRH ‐A treatment resulted in reduced scar mass ( GHRH ‐A: −21.9±6.42%; P =0.02; placebo: 10.9±5.88%; P =0.25; 2‐way ANOVA ; P =0.003), and scar size (percentage of left ventricular mass) ( GHRH ‐A: −38.38±4.63; P =0.0002; placebo: −14.56±6.92; P =0.16; 2‐way ANOVA ; P =0.02). This was accompanied by improved diastolic strain. Unlike in rats, this reduced infarct size in swine was not accompanied by improved cardiac function as measured by serial hemodynamic pressure–volume analysis. GHRH receptors were abundant in cardiac tissue, with a greater density in the border zone of the GHRH ‐A group compared with the placebo group. Conclusions Daily subcutaneous administration of GHRH ‐A is feasible and safe in a large animal model of subacute ischemic cardiomyopathy. Furthermore, GHRH ‐A therapy significantly reduced infarct size and improved diastolic strain, suggesting a local activation of the GHRH pathway leading to the reparative process." @default.
- W2022211087 created "2016-06-24" @default.
- W2022211087 creator A5002242141 @default.
- W2022211087 creator A5007553347 @default.
- W2022211087 creator A5008640997 @default.
- W2022211087 creator A5010505641 @default.
- W2022211087 creator A5021152255 @default.
- W2022211087 creator A5025393689 @default.
- W2022211087 creator A5026849905 @default.
- W2022211087 creator A5038486715 @default.
- W2022211087 creator A5045570058 @default.
- W2022211087 creator A5046190479 @default.
- W2022211087 creator A5054726478 @default.
- W2022211087 creator A5056168495 @default.
- W2022211087 creator A5068564667 @default.
- W2022211087 creator A5068739269 @default.
- W2022211087 creator A5076390557 @default.
- W2022211087 creator A5078415535 @default.
- W2022211087 creator A5085774808 @default.
- W2022211087 creator A5086268360 @default.
- W2022211087 creator A5087753341 @default.
- W2022211087 date "2015-04-22" @default.
- W2022211087 modified "2023-10-17" @default.
- W2022211087 title "Growth Hormone–Releasing Hormone Agonists Reduce Myocardial Infarct Scar in Swine With Subacute Ischemic Cardiomyopathy" @default.
- W2022211087 cites W1514303257 @default.
- W2022211087 cites W1562826552 @default.
- W2022211087 cites W1904802773 @default.
- W2022211087 cites W1966225408 @default.
- W2022211087 cites W1969318893 @default.
- W2022211087 cites W1975703863 @default.
- W2022211087 cites W1978744153 @default.
- W2022211087 cites W1981724886 @default.
- W2022211087 cites W1983374780 @default.
- W2022211087 cites W1985672849 @default.
- W2022211087 cites W1988146076 @default.
- W2022211087 cites W1989667776 @default.
- W2022211087 cites W1995266004 @default.
- W2022211087 cites W1995624217 @default.
- W2022211087 cites W2000949542 @default.
- W2022211087 cites W2005610478 @default.
- W2022211087 cites W2017751753 @default.
- W2022211087 cites W2029872197 @default.
- W2022211087 cites W2046431829 @default.
- W2022211087 cites W2061365886 @default.
- W2022211087 cites W2062765739 @default.
- W2022211087 cites W2070790284 @default.
- W2022211087 cites W2080336584 @default.
- W2022211087 cites W2104504193 @default.
- W2022211087 cites W2105144228 @default.
- W2022211087 cites W2112777549 @default.
- W2022211087 cites W2124724401 @default.
- W2022211087 cites W2135236486 @default.
- W2022211087 cites W2141844425 @default.
- W2022211087 cites W2143719911 @default.
- W2022211087 cites W2147998669 @default.
- W2022211087 cites W2151749410 @default.
- W2022211087 cites W2156627753 @default.
- W2022211087 cites W2160616769 @default.
- W2022211087 cites W2161404635 @default.
- W2022211087 cites W2161947705 @default.
- W2022211087 cites W2163617648 @default.
- W2022211087 cites W2321832844 @default.
- W2022211087 cites W2336383135 @default.
- W2022211087 cites W2462357222 @default.
- W2022211087 cites W2548233613 @default.
- W2022211087 cites W31277953 @default.
- W2022211087 doi "https://doi.org/10.1161/jaha.114.001464" @default.
- W2022211087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4579962" @default.
- W2022211087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25827134" @default.
- W2022211087 hasPublicationYear "2015" @default.
- W2022211087 type Work @default.
- W2022211087 sameAs 2022211087 @default.
- W2022211087 citedByCount "26" @default.
- W2022211087 countsByYear W20222110872016 @default.
- W2022211087 countsByYear W20222110872017 @default.
- W2022211087 countsByYear W20222110872018 @default.
- W2022211087 countsByYear W20222110872019 @default.
- W2022211087 countsByYear W20222110872020 @default.
- W2022211087 countsByYear W20222110872021 @default.
- W2022211087 countsByYear W20222110872022 @default.
- W2022211087 countsByYear W20222110872023 @default.
- W2022211087 crossrefType "journal-article" @default.
- W2022211087 hasAuthorship W2022211087A5002242141 @default.
- W2022211087 hasAuthorship W2022211087A5007553347 @default.
- W2022211087 hasAuthorship W2022211087A5008640997 @default.
- W2022211087 hasAuthorship W2022211087A5010505641 @default.
- W2022211087 hasAuthorship W2022211087A5021152255 @default.
- W2022211087 hasAuthorship W2022211087A5025393689 @default.
- W2022211087 hasAuthorship W2022211087A5026849905 @default.
- W2022211087 hasAuthorship W2022211087A5038486715 @default.
- W2022211087 hasAuthorship W2022211087A5045570058 @default.
- W2022211087 hasAuthorship W2022211087A5046190479 @default.
- W2022211087 hasAuthorship W2022211087A5054726478 @default.
- W2022211087 hasAuthorship W2022211087A5056168495 @default.
- W2022211087 hasAuthorship W2022211087A5068564667 @default.
- W2022211087 hasAuthorship W2022211087A5068739269 @default.
- W2022211087 hasAuthorship W2022211087A5076390557 @default.
- W2022211087 hasAuthorship W2022211087A5078415535 @default.
- W2022211087 hasAuthorship W2022211087A5085774808 @default.
- W2022211087 hasAuthorship W2022211087A5086268360 @default.