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- W2022211255 abstract "Low-dose IL-2 administration can control autoimmunity by specifically activating CD4+ Foxp3+ regulatory T cells (Tregs). Here, we studied IL-2-based immunotherapy in experimental graft-versus-host disease (GVHD). IL-2 administration to donor mice induced a dose-dependent expansion of Tregs in the graft but was insufficient to control GVHD. IL-2 administration to allogeneic-grafted recipient mice activated T-conventional cells (Tcons) and did not prevent GVHD. This loss of IL-2 selectivity toward Tregs was explained by an IL-2-induced increase in the IL-2 receptor α-chain expression on Tcons. Finally, in xeno-GVHD generated by human PBMCs transplanted into immunodeficient mice, low-dose IL-2 increased Treg frequencies but did neither control pro-inflammatory cytokine production by pathogenic Tcons, nor prevented GVHD. Furthermore, combination of low-dose IL-2 with rapamycin was ineffective in this model. Our results indicate that limitations on the use of IL-2 during acute GVHD are likely due to the massive activation of the allogeneic T cells unique to this setting." @default.
- W2022211255 created "2016-06-24" @default.
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- W2022211255 date "2014-12-01" @default.
- W2022211255 modified "2023-10-16" @default.
- W2022211255 title "Potential limitations of IL-2 administration for the treatment of experimental acute graft-versus-host disease" @default.
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- W2022211255 doi "https://doi.org/10.1016/j.imlet.2014.10.027" @default.
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