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- W2022212072 abstract "Botulinum neurotoxins (BoNTs) are the most toxic proteins in nature. Rapid and sensitive detection of BoNTs is achieved by the endopeptidase–mass spectrometry (Endopep–MS) assay. In this assay, BoNT cleaves a specific peptide substrate and the cleaved products are analyzed by MS. Here we describe the design of a new peptide substrate for improved detection of BoNT type B (BoNT/B) in the Endopep–MS assay. Our strategy was based on reported BoNT/B–substrate interactions integrated with analysis method efficiency considerations. Incorporation of the new peptide led to a 5-fold increased sensitivity of the assay both in buffer and in a clinically relevant human spiked serum." @default.
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- W2022212072 date "1996-07-01" @default.
- W2022212072 modified "2023-09-24" @default.
- W2022212072 title "Letter Qingjian Wang and Rajendra Raghow" @default.
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- W2022212072 doi "https://doi.org/10.1016/s0945-053x(96)90143-2" @default.
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