Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022215187> ?p ?o ?g. }
- W2022215187 endingPage "490" @default.
- W2022215187 startingPage "472" @default.
- W2022215187 abstract "N-Phenylanthranilic acid (NPAA) causes renal papillary necrosis (RPN) in the rat following repeated oral dosing. Non-invasive early detection of RPN is difficult, but a number of potential biomarkers have been investigated, including phospholipid and uronic acid excretion. This study used 1H-nuclear magnetic resonance (NMR) spectroscopic analysis of urine to investigate urinary metabolic perturbations occurring in the rat following exposure to NPAA. Male Alderley Park rats received NPAA (300, 500 or 700 mg kg(-1) day(-1) orally) for 7 days, and urine was collected on days 7-8, 14-15, 21-22 and 28-29. In a separate study, urine was collected on days 1-2, 3-4, 5-6 and 7-8 from rats receiving 500 mg kg(-1) day(-1). Samples were analysed by 1H NMR spectroscopy combined with multivariate data analysis and clinical chemistry. Histopathology and clinical chemistry analysis of terminal blood samples was carried out following termination on days 4, 6, 8 and 29 (4 week time course) and days 2, 4, 6 and 8 (8 day study). Urine analysis revealed a marked, though variable, excretion of beta-hydroxybutyrate, acetoacetate and acetone (ketone bodies) seen on days 3-4, 5-6 and 7-8 of the study. It is postulated that the ketonuria might be secondary to an alteration in fatty acid metabolism due to inhibition of prostaglandin synthesis. In addition, an elevation in urinary ascorbate was observed during the first 8 days of the study. Ascorbate is considered to be a biomarker of hepatic response, probably reflecting an increased hepatic activity due to glucuronidation of NPAA." @default.
- W2022215187 created "2016-06-24" @default.
- W2022215187 creator A5007055169 @default.
- W2022215187 creator A5007314439 @default.
- W2022215187 creator A5014308951 @default.
- W2022215187 creator A5025966066 @default.
- W2022215187 creator A5051977353 @default.
- W2022215187 creator A5074825053 @default.
- W2022215187 creator A5084974155 @default.
- W2022215187 date "2003-11-01" @default.
- W2022215187 modified "2023-10-12" @default.
- W2022215187 title "<sup>1</sup>H-Nuclear magnetic resonance pattern recognition studies with<i>N</i>-phenylanthranilic acid in the rat: time- and dose-related metabolic effects" @default.
- W2022215187 cites W1956726201 @default.
- W2022215187 cites W1977018034 @default.
- W2022215187 cites W1981939403 @default.
- W2022215187 cites W1986095466 @default.
- W2022215187 cites W2004746596 @default.
- W2022215187 cites W2006945305 @default.
- W2022215187 cites W2007013530 @default.
- W2022215187 cites W2010969241 @default.
- W2022215187 cites W2026925186 @default.
- W2022215187 cites W2030649751 @default.
- W2022215187 cites W2033151638 @default.
- W2022215187 cites W2038849352 @default.
- W2022215187 cites W2058153424 @default.
- W2022215187 cites W2065985435 @default.
- W2022215187 cites W2068176429 @default.
- W2022215187 cites W2072464766 @default.
- W2022215187 cites W2073441678 @default.
- W2022215187 cites W2089319642 @default.
- W2022215187 cites W2089874093 @default.
- W2022215187 cites W2090419653 @default.
- W2022215187 cites W2104296516 @default.
- W2022215187 cites W2140793116 @default.
- W2022215187 cites W2316486670 @default.
- W2022215187 cites W4320800981 @default.
- W2022215187 cites W2064950318 @default.
- W2022215187 cites W2168986800 @default.
- W2022215187 doi "https://doi.org/10.1080/13547500310001647030" @default.
- W2022215187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15195679" @default.
- W2022215187 hasPublicationYear "2003" @default.
- W2022215187 type Work @default.
- W2022215187 sameAs 2022215187 @default.
- W2022215187 citedByCount "17" @default.
- W2022215187 countsByYear W20222151872012 @default.
- W2022215187 countsByYear W20222151872013 @default.
- W2022215187 countsByYear W20222151872014 @default.
- W2022215187 countsByYear W20222151872015 @default.
- W2022215187 countsByYear W20222151872018 @default.
- W2022215187 crossrefType "journal-article" @default.
- W2022215187 hasAuthorship W2022215187A5007055169 @default.
- W2022215187 hasAuthorship W2022215187A5007314439 @default.
- W2022215187 hasAuthorship W2022215187A5014308951 @default.
- W2022215187 hasAuthorship W2022215187A5025966066 @default.
- W2022215187 hasAuthorship W2022215187A5051977353 @default.
- W2022215187 hasAuthorship W2022215187A5074825053 @default.
- W2022215187 hasAuthorship W2022215187A5084974155 @default.
- W2022215187 hasConcept C10146269 @default.
- W2022215187 hasConcept C126322002 @default.
- W2022215187 hasConcept C134018914 @default.
- W2022215187 hasConcept C142724271 @default.
- W2022215187 hasConcept C185592680 @default.
- W2022215187 hasConcept C2779225474 @default.
- W2022215187 hasConcept C2780026642 @default.
- W2022215187 hasConcept C31532488 @default.
- W2022215187 hasConcept C544855455 @default.
- W2022215187 hasConcept C55493867 @default.
- W2022215187 hasConcept C62231903 @default.
- W2022215187 hasConcept C71924100 @default.
- W2022215187 hasConcept C77411442 @default.
- W2022215187 hasConceptScore W2022215187C10146269 @default.
- W2022215187 hasConceptScore W2022215187C126322002 @default.
- W2022215187 hasConceptScore W2022215187C134018914 @default.
- W2022215187 hasConceptScore W2022215187C142724271 @default.
- W2022215187 hasConceptScore W2022215187C185592680 @default.
- W2022215187 hasConceptScore W2022215187C2779225474 @default.
- W2022215187 hasConceptScore W2022215187C2780026642 @default.
- W2022215187 hasConceptScore W2022215187C31532488 @default.
- W2022215187 hasConceptScore W2022215187C544855455 @default.
- W2022215187 hasConceptScore W2022215187C55493867 @default.
- W2022215187 hasConceptScore W2022215187C62231903 @default.
- W2022215187 hasConceptScore W2022215187C71924100 @default.
- W2022215187 hasConceptScore W2022215187C77411442 @default.
- W2022215187 hasIssue "6" @default.
- W2022215187 hasLocation W20222151871 @default.
- W2022215187 hasLocation W20222151872 @default.
- W2022215187 hasOpenAccess W2022215187 @default.
- W2022215187 hasPrimaryLocation W20222151871 @default.
- W2022215187 hasRelatedWork W147648439 @default.
- W2022215187 hasRelatedWork W2002536018 @default.
- W2022215187 hasRelatedWork W2371589734 @default.
- W2022215187 hasRelatedWork W2394092719 @default.
- W2022215187 hasRelatedWork W2539168248 @default.
- W2022215187 hasRelatedWork W2772070920 @default.
- W2022215187 hasRelatedWork W2794691580 @default.
- W2022215187 hasRelatedWork W2903787371 @default.
- W2022215187 hasRelatedWork W2971700887 @default.
- W2022215187 hasRelatedWork W4318259926 @default.