FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022220260> ?p ?o ?g. }

• W2022220260 endingPage "374" @default.
• W2022220260 startingPage "364" @default.
• W2022220260 abstract "Heat shock protein 70 (Hsp70) release and its effects on pro-inflammatory cytokine production have been controversial. In this study, we investigated whether Hsp70 could be released from monocytes and activates matrix metalloproteinase-9 (MMP-9) gene expression. Hsp70 overexpression in human monocytic cell line U937 was found to increase PMA- induced MMP-9 expression and enhance cell motility. Hsp70 cDNA transfectants released Hsp70 protein into culture supernatants, and a part of released Hsp70 subsequently was bound to the surface of U937 cells. Addition of culture medium containing the extracelluar Hsp70 led to an increase not only in proMMP-9 secretion, but also the invasiveness of U937 cells through Matrigel or human umbilical vascular endothelial cells (HUVEC) in vitro. Immunodepletion of Hsp70 abolished its effect on MMP-9 expression. The released Hsp70 activated nuclear factor κ B (NF-κ B) and activating protein-1 (AP-1), which led to the activation of MMP-9 transcription. Taken together, these results suggest that extracellular Hsp70 induces the expression of MMP-9 gene through activation of NF-κ B and AP-1." @default.
• W2022220260 created "2016-06-24" @default.
• W2022220260 creator A5007789858 @default.
• W2022220260 creator A5028277613 @default.
• W2022220260 creator A5032616453 @default.
• W2022220260 creator A5033226635 @default.
• W2022220260 creator A5051286320 @default.
• W2022220260 creator A5057017443 @default.
• W2022220260 creator A5063455319 @default.
• W2022220260 creator A5067392576 @default.
• W2022220260 creator A5068527459 @default.
• W2022220260 creator A5070852030 @default.
• W2022220260 creator A5081311934 @default.
• W2022220260 date "2006-08-01" @default.
• W2022220260 modified "2023-10-09" @default.
• W2022220260 title "Release of heat shock protein 70 (Hsp70) and the effects of extracellular Hsp70 on matric metalloproteinase-9 expression in human monocytic U937 cells" @default.
• W2022220260 doi "https://doi.org/10.1038/emm.2006.43" @default.
• W2022220260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16953115" @default.
• W2022220260 hasPublicationYear "2006" @default.
• W2022220260 type Work @default.
• W2022220260 sameAs 2022220260 @default.
• W2022220260 citedByCount "48" @default.
• W2022220260 countsByYear W20222202602012 @default.
• W2022220260 countsByYear W20222202602013 @default.
• W2022220260 countsByYear W20222202602014 @default.
• W2022220260 countsByYear W20222202602015 @default.
• W2022220260 countsByYear W20222202602016 @default.
• W2022220260 countsByYear W20222202602017 @default.
• W2022220260 countsByYear W20222202602018 @default.
• W2022220260 countsByYear W20222202602019 @default.
• W2022220260 countsByYear W20222202602020 @default.
• W2022220260 countsByYear W20222202602021 @default.
• W2022220260 countsByYear W20222202602022 @default.
• W2022220260 crossrefType "journal-article" @default.
• W2022220260 hasAuthorship W2022220260A5007789858 @default.
• W2022220260 hasAuthorship W2022220260A5028277613 @default.
• W2022220260 hasAuthorship W2022220260A5032616453 @default.
• W2022220260 hasAuthorship W2022220260A5033226635 @default.
• W2022220260 hasAuthorship W2022220260A5051286320 @default.
• W2022220260 hasAuthorship W2022220260A5057017443 @default.
• W2022220260 hasAuthorship W2022220260A5063455319 @default.
• W2022220260 hasAuthorship W2022220260A5067392576 @default.
• W2022220260 hasAuthorship W2022220260A5068527459 @default.
• W2022220260 hasAuthorship W2022220260A5070852030 @default.
• W2022220260 hasAuthorship W2022220260A5081311934 @default.
• W2022220260 hasBestOaLocation W20222202601 @default.
• W2022220260 hasConcept C104317684 @default.
• W2022220260 hasConcept C108634530 @default.
• W2022220260 hasConcept C109523444 @default.
• W2022220260 hasConcept C129527566 @default.
• W2022220260 hasConcept C150194340 @default.
• W2022220260 hasConcept C153911025 @default.
• W2022220260 hasConcept C203014093 @default.
• W2022220260 hasConcept C205260736 @default.
• W2022220260 hasConcept C2778608917 @default.
• W2022220260 hasConcept C2778690821 @default.
• W2022220260 hasConcept C2781184567 @default.
• W2022220260 hasConcept C54355233 @default.
• W2022220260 hasConcept C55493867 @default.
• W2022220260 hasConcept C68991219 @default.
• W2022220260 hasConcept C81885089 @default.
• W2022220260 hasConcept C86803240 @default.
• W2022220260 hasConcept C95444343 @default.
• W2022220260 hasConceptScore W2022220260C104317684 @default.
• W2022220260 hasConceptScore W2022220260C108634530 @default.
• W2022220260 hasConceptScore W2022220260C109523444 @default.
• W2022220260 hasConceptScore W2022220260C129527566 @default.
• W2022220260 hasConceptScore W2022220260C150194340 @default.
• W2022220260 hasConceptScore W2022220260C153911025 @default.
• W2022220260 hasConceptScore W2022220260C203014093 @default.
• W2022220260 hasConceptScore W2022220260C205260736 @default.
• W2022220260 hasConceptScore W2022220260C2778608917 @default.
• W2022220260 hasConceptScore W2022220260C2778690821 @default.
• W2022220260 hasConceptScore W2022220260C2781184567 @default.
• W2022220260 hasConceptScore W2022220260C54355233 @default.
• W2022220260 hasConceptScore W2022220260C55493867 @default.
• W2022220260 hasConceptScore W2022220260C68991219 @default.
• W2022220260 hasConceptScore W2022220260C81885089 @default.
• W2022220260 hasConceptScore W2022220260C86803240 @default.
• W2022220260 hasConceptScore W2022220260C95444343 @default.
• W2022220260 hasIssue "4" @default.
• W2022220260 hasLocation W20222202601 @default.
• W2022220260 hasLocation W20222202602 @default.
• W2022220260 hasOpenAccess W2022220260 @default.
• W2022220260 hasPrimaryLocation W20222202601 @default.
• W2022220260 hasRelatedWork W2022220260 @default.
• W2022220260 hasRelatedWork W2066706221 @default.
• W2022220260 hasRelatedWork W2076389425 @default.
• W2022220260 hasRelatedWork W2082451309 @default.
• W2022220260 hasRelatedWork W2349278031 @default.
• W2022220260 hasRelatedWork W2370296656 @default.
• W2022220260 hasRelatedWork W2379220137 @default.
• W2022220260 hasRelatedWork W2431010602 @default.
• W2022220260 hasRelatedWork W2896125589 @default.
• W2022220260 hasRelatedWork W3150918846 @default.
• W2022220260 hasVolume "38" @default.
• W2022220260 isParatext "false" @default.
• W2022220260 isRetracted "false" @default.

• next