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• W2022220869 abstract "Tie-2 is a receptor tyrosine kinase which is involved in angiogenesis and thereby growth of human tumours. The discovery and SAR of a novel class of imidazole-vinyl-pyrimidine kinase inhibitors, which inhibit Tie-2 in vitro is reported. Their synthesis was carried out by condensation of imidazole aldehydes with methyl pyrimidines. These compounds are lead-like, with low molecular weight, good physical properties and oral bioavailability." @default.
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• W2022220869 date "2008-08-01" @default.
• W2022220869 modified "2023-09-26" @default.
• W2022220869 title "Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable" @default.
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• W2022220869 doi "https://doi.org/10.1016/j.bmcl.2008.06.106" @default.
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