Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022221011> ?p ?o ?g. }
- W2022221011 endingPage "9376" @default.
- W2022221011 startingPage "9371" @default.
- W2022221011 abstract "It has long been hypothesized that morphological and numerical alterations in dendritic spines underlie long-term structural encoding of experiences. Here we investigate the efficacy of aversive experience in the form of acute immobilization stress (AIS) and chronic immobilization stress (CIS) in modulating spine density in the basolateral amygdala (BLA) of male rats. We find that CIS elicits a robust increase in spine density across primary and secondary branches of BLA spiny neurons. We observed this CIS-induced spinogenesis in the BLA 1 d after the termination of CIS. In contrast, AIS fails to affect spine density or dendritic arborization when measured 1 d later. Strikingly, the same AIS causes a gradual increase in spine density 10 d later but without any effect on dendritic arbors. Thus, by modulating the duration of immobilization stress, it is possible to induce the formation of new spines without remodeling dendrites. However, unlike CIS-induced spine formation, the gradual increase in spine density 10 d after a single exposure to AIS is localized on primary dendrites. Finally, this delayed induction of BLA spinogenesis is paralleled by a gradual development of anxiety-like behavior on the elevated plus-maze 10 d after AIS. These findings demonstrate that stressful experiences can lead to the formation of new dendritic spines in the BLA, which is believed to be a locus of storage for fear memories. Our results also suggest that stress may facilitate symptoms of chronic anxiety disorders like post-traumatic stress disorder by enhancing synaptic connectivity in the BLA." @default.
- W2022221011 created "2016-06-24" @default.
- W2022221011 creator A5000059723 @default.
- W2022221011 creator A5005546626 @default.
- W2022221011 creator A5014789927 @default.
- W2022221011 creator A5035103174 @default.
- W2022221011 creator A5076893439 @default.
- W2022221011 date "2005-06-20" @default.
- W2022221011 modified "2023-10-14" @default.
- W2022221011 title "Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala" @default.
- W2022221011 cites W1479736082 @default.
- W2022221011 cites W1494500191 @default.
- W2022221011 cites W151176851 @default.
- W2022221011 cites W1572640432 @default.
- W2022221011 cites W1628708546 @default.
- W2022221011 cites W1642243794 @default.
- W2022221011 cites W1677457722 @default.
- W2022221011 cites W1703928766 @default.
- W2022221011 cites W1840705577 @default.
- W2022221011 cites W1914486736 @default.
- W2022221011 cites W1963209155 @default.
- W2022221011 cites W1964250712 @default.
- W2022221011 cites W1965313832 @default.
- W2022221011 cites W1969188229 @default.
- W2022221011 cites W1971734491 @default.
- W2022221011 cites W1973774008 @default.
- W2022221011 cites W1977662196 @default.
- W2022221011 cites W1985738573 @default.
- W2022221011 cites W1986620970 @default.
- W2022221011 cites W1991842868 @default.
- W2022221011 cites W1998529665 @default.
- W2022221011 cites W2004337408 @default.
- W2022221011 cites W2004643104 @default.
- W2022221011 cites W2012458220 @default.
- W2022221011 cites W2018546099 @default.
- W2022221011 cites W2023648659 @default.
- W2022221011 cites W2024583667 @default.
- W2022221011 cites W2026873245 @default.
- W2022221011 cites W2034456670 @default.
- W2022221011 cites W2035071372 @default.
- W2022221011 cites W2036940384 @default.
- W2022221011 cites W2039508969 @default.
- W2022221011 cites W2042402461 @default.
- W2022221011 cites W2045861732 @default.
- W2022221011 cites W2047689667 @default.
- W2022221011 cites W2058317952 @default.
- W2022221011 cites W2059082849 @default.
- W2022221011 cites W2064212981 @default.
- W2022221011 cites W2064227979 @default.
- W2022221011 cites W2066686316 @default.
- W2022221011 cites W2067459313 @default.
- W2022221011 cites W2068837044 @default.
- W2022221011 cites W2075164262 @default.
- W2022221011 cites W2079882829 @default.
- W2022221011 cites W2083642822 @default.
- W2022221011 cites W2090116050 @default.
- W2022221011 cites W2091064369 @default.
- W2022221011 cites W2092713465 @default.
- W2022221011 cites W2096229412 @default.
- W2022221011 cites W2096456461 @default.
- W2022221011 cites W2096610613 @default.
- W2022221011 cites W2104180981 @default.
- W2022221011 cites W2104281927 @default.
- W2022221011 cites W2106766347 @default.
- W2022221011 cites W2111916392 @default.
- W2022221011 cites W2114168188 @default.
- W2022221011 cites W2121403142 @default.
- W2022221011 cites W2127186613 @default.
- W2022221011 cites W2130196728 @default.
- W2022221011 cites W2136403062 @default.
- W2022221011 cites W2145643383 @default.
- W2022221011 cites W2148389554 @default.
- W2022221011 cites W2154836288 @default.
- W2022221011 cites W2158553737 @default.
- W2022221011 cites W2162407586 @default.
- W2022221011 cites W2167165150 @default.
- W2022221011 cites W2167820351 @default.
- W2022221011 cites W2171103528 @default.
- W2022221011 cites W2176569267 @default.
- W2022221011 cites W4231738588 @default.
- W2022221011 cites W4233270027 @default.
- W2022221011 cites W4233643243 @default.
- W2022221011 cites W4362207762 @default.
- W2022221011 cites W52300898 @default.
- W2022221011 doi "https://doi.org/10.1073/pnas.0504011102" @default.
- W2022221011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1166638" @default.
- W2022221011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15967994" @default.
- W2022221011 hasPublicationYear "2005" @default.
- W2022221011 type Work @default.
- W2022221011 sameAs 2022221011 @default.
- W2022221011 citedByCount "555" @default.
- W2022221011 countsByYear W20222210112012 @default.
- W2022221011 countsByYear W20222210112013 @default.
- W2022221011 countsByYear W20222210112014 @default.
- W2022221011 countsByYear W20222210112015 @default.
- W2022221011 countsByYear W20222210112016 @default.
- W2022221011 countsByYear W20222210112017 @default.
- W2022221011 countsByYear W20222210112018 @default.