Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022221661> ?p ?o ?g. }
- W2022221661 endingPage "28532" @default.
- W2022221661 startingPage "28520" @default.
- W2022221661 abstract "Nodal and Smad2/3 signals play pivotal roles in mesendoderm induction and axis determination during late blastulation and early gastrulation in vertebrate embryos. However, Smad2/3 direct target genes during those critical developmental stages have not been systematically identified. Here, through ChIP-chip assay, we show that the promoter/enhancer regions of 679 genes are bound by Smad2 in the zebrafish early gastrulas. Expression analyses confirm that a significant proportion of Smad2 targets are indeed subjected to Nodal/Smad2 regulation at the onset of gastrulation. The co-existence of DNA-binding sites of other transcription factors in the Smad2-bound regions allows the identification of well known Smad2-binding partners, such as FoxH1 and Lef1/β-catenin, as well as many previously unknown Smad2 partners, including Oct1 and Gata6, during embryogenesis. We demonstrate that Oct1 physically associates with and enhances the transcription and mesendodermal induction activity of Smad2, whereas Gata6 exerts an inhibitory role in Smad2 signaling and mesendodermal induction. Thus, our study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription, which will be valuable for studying regulatory cascades during germ layer formation and patterning of vertebrate embryos." @default.
- W2022221661 created "2016-06-24" @default.
- W2022221661 creator A5003285450 @default.
- W2022221661 creator A5003916393 @default.
- W2022221661 creator A5010994200 @default.
- W2022221661 creator A5035193785 @default.
- W2022221661 creator A5039029874 @default.
- W2022221661 creator A5066585954 @default.
- W2022221661 creator A5070667136 @default.
- W2022221661 creator A5090080418 @default.
- W2022221661 date "2011-08-01" @default.
- W2022221661 modified "2023-09-26" @default.
- W2022221661 title "Global Identification of SMAD2 Target Genes Reveals a Role for Multiple Co-regulatory Factors in Zebrafish Early Gastrulas" @default.
- W2022221661 cites W1489916230 @default.
- W2022221661 cites W1515719112 @default.
- W2022221661 cites W1527223408 @default.
- W2022221661 cites W1532872348 @default.
- W2022221661 cites W1533376056 @default.
- W2022221661 cites W1701092691 @default.
- W2022221661 cites W1961074127 @default.
- W2022221661 cites W1971175769 @default.
- W2022221661 cites W1972619403 @default.
- W2022221661 cites W1976880781 @default.
- W2022221661 cites W1977001077 @default.
- W2022221661 cites W1985406652 @default.
- W2022221661 cites W1985929046 @default.
- W2022221661 cites W1989307537 @default.
- W2022221661 cites W1989874642 @default.
- W2022221661 cites W1991819480 @default.
- W2022221661 cites W2003475800 @default.
- W2022221661 cites W2008743321 @default.
- W2022221661 cites W2011687097 @default.
- W2022221661 cites W2019598289 @default.
- W2022221661 cites W2021226726 @default.
- W2022221661 cites W2024821862 @default.
- W2022221661 cites W2026428548 @default.
- W2022221661 cites W2034552950 @default.
- W2022221661 cites W2043847135 @default.
- W2022221661 cites W2046648305 @default.
- W2022221661 cites W2047522987 @default.
- W2022221661 cites W2048667426 @default.
- W2022221661 cites W2050175272 @default.
- W2022221661 cites W2052071230 @default.
- W2022221661 cites W2054778053 @default.
- W2022221661 cites W2063023858 @default.
- W2022221661 cites W2070476550 @default.
- W2022221661 cites W2072000337 @default.
- W2022221661 cites W2073977744 @default.
- W2022221661 cites W2074773822 @default.
- W2022221661 cites W2078058386 @default.
- W2022221661 cites W2082144118 @default.
- W2022221661 cites W2082955515 @default.
- W2022221661 cites W2090596888 @default.
- W2022221661 cites W2091055964 @default.
- W2022221661 cites W2093543973 @default.
- W2022221661 cites W2095409357 @default.
- W2022221661 cites W2095718954 @default.
- W2022221661 cites W2097923096 @default.
- W2022221661 cites W2098094337 @default.
- W2022221661 cites W2100668965 @default.
- W2022221661 cites W2103017472 @default.
- W2022221661 cites W2103381667 @default.
- W2022221661 cites W2111391000 @default.
- W2022221661 cites W2113833510 @default.
- W2022221661 cites W2117200840 @default.
- W2022221661 cites W2120006551 @default.
- W2022221661 cites W2120865735 @default.
- W2022221661 cites W2122535550 @default.
- W2022221661 cites W2125349610 @default.
- W2022221661 cites W2127043599 @default.
- W2022221661 cites W2127906347 @default.
- W2022221661 cites W2128827916 @default.
- W2022221661 cites W2135030836 @default.
- W2022221661 cites W2135854261 @default.
- W2022221661 cites W2141860100 @default.
- W2022221661 cites W2145055902 @default.
- W2022221661 cites W2146167376 @default.
- W2022221661 cites W2147350988 @default.
- W2022221661 cites W2154568166 @default.
- W2022221661 cites W2156212940 @default.
- W2022221661 cites W4235438234 @default.
- W2022221661 doi "https://doi.org/10.1074/jbc.m111.236307" @default.
- W2022221661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3151094" @default.
- W2022221661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21669877" @default.
- W2022221661 hasPublicationYear "2011" @default.
- W2022221661 type Work @default.
- W2022221661 sameAs 2022221661 @default.
- W2022221661 citedByCount "52" @default.
- W2022221661 countsByYear W20222216612012 @default.
- W2022221661 countsByYear W20222216612013 @default.
- W2022221661 countsByYear W20222216612014 @default.
- W2022221661 countsByYear W20222216612015 @default.
- W2022221661 countsByYear W20222216612016 @default.
- W2022221661 countsByYear W20222216612017 @default.
- W2022221661 countsByYear W20222216612018 @default.
- W2022221661 countsByYear W20222216612019 @default.
- W2022221661 countsByYear W20222216612020 @default.
- W2022221661 countsByYear W20222216612021 @default.