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• W2022222317 startingPage "3058" @default.
• W2022222317 abstract "The Ras oncogene transforms cultured murine fibroblasts into malignant, focus-forming cells, whose lack of contact inhibition is evidenced by high saturation densities. In order to investigate the reversibility of Ras transformation, as well as the kinetics of Ras-induced changes, cell lines that conditionally express oncogenic Ras were constructed. Both focus formation and increased saturation density were inducible and fully reversible. In exponentially growing cells, oncogenic Ras-expression had no effect on proliferation rates, Erk phosphorylation, or the level of cyclin D1, and Ras-induction did not confer serum-independent growth. As expected, growth to high density in uninduced cells led to quiescence with a low level of cyclin D1 and no active Erk; in this setting, Ras induction prevented full downregulation of cyclin D1 and inactivation of Erk. Our results show that Ras expression to a level sufficient for transformation leads to relatively subtle effects on known downstream targets, and that the focus formation and increased saturation density growth induced by Ras is not a result of growth factor independence." @default.
• W2022222317 created "2016-06-24" @default.
• W2022222317 creator A5026071552 @default.
• W2022222317 creator A5036377196 @default.
• W2022222317 creator A5087145202 @default.
• W2022222317 date "2002-05-02" @default.
• W2022222317 modified "2023-10-17" @default.
• W2022222317 title "Ras-inducible immortalized fibroblasts: focus formation without cell cycle deregulation" @default.
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• W2022222317 doi "https://doi.org/10.1038/sj.onc.1205423" @default.
• W2022222317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12082537" @default.
• W2022222317 hasPublicationYear "2002" @default.
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