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- W2022222443 abstract "Abstract Introduction: In this study we compared the effects of downhill or horizontal treadmill running on the magnetic resonance imaging (MRI) transverse relaxation time constant (T 2 ) in mdx mice. Methods: Mice underwent either downhill ( n = 11 mdx , n = 6 controls) or horizontal running ( n = 9, mdx only) on a treadmill. MRI was conducted prior to exercise, immediately afterward (∽20 minutes), and then 24 and 48 hours after exercise. Results: A higher percentage of pixels with elevated T 2 in the lower hindlimb muscles was observed in the mdx mice compared with controls both pre‐exercise ( P < 0.001) and at each time‐point after downhill running ( P < 0.05), but not with horizontal running. The medial compartment muscles appeared to be the most susceptible to increased T 2 . Conclusions: Downhill running provides a stimulus for inducing acute changes in muscle T 2 in mdx mice. MRI is a non‐invasive approach for examining acute muscle damage and recovery in multiple muscle groups simultaneously. Muscle Nerve, 2010." @default.
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- W2022222443 date "2011-04-12" @default.
- W2022222443 modified "2023-10-18" @default.
- W2022222443 title "Changes in muscle T2 and tissue damage after downhill running in mdx Mice" @default.
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- W2022222443 doi "https://doi.org/10.1002/mus.21986" @default.
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