FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022222793> ?p ?o ?g. }

• W2022222793 endingPage "2231" @default.
• W2022222793 startingPage "2229" @default.
• W2022222793 abstract "Botulinum neurotoxins (BoNTs) are the most toxic proteins currently known. Current treatments for botulinum poisoning are all protein based with a limited window of opportunity. Inhibition of the BoNT light chain protease (LC) has emerged as a new therapeutic strategy for the treatment of botulism as it may provide an effective post-exposure remedy. As such, a small library of 40 betulin derivatives was synthesized and screened against the light chain of BoNT serotype A (LC/A); five positive hits (IC(50) <100 μM) were uncovered. Detailed evaluation of inhibition mechanism of three most active compounds revealed a competitive model, with sub-micromolar K(i) value for the best inhibitor (7). Unfortunately, an in vitro cell-based assay did not show any protection of rat cerebellar neurons against BoNT/A intoxication by 7." @default.
• W2022222793 created "2016-06-24" @default.
• W2022222793 creator A5010846884 @default.
• W2022222793 creator A5024312004 @default.
• W2022222793 creator A5034253457 @default.
• W2022222793 creator A5035202093 @default.
• W2022222793 creator A5073379520 @default.
• W2022222793 creator A5077133720 @default.
• W2022222793 creator A5091485962 @default.
• W2022222793 date "2011-04-01" @default.
• W2022222793 modified "2023-10-17" @default.
• W2022222793 title "Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease" @default.
• W2022222793 cites W1968448491 @default.
• W2022222793 cites W1970220792 @default.
• W2022222793 cites W1973022679 @default.
• W2022222793 cites W1992067885 @default.
• W2022222793 cites W1992347298 @default.
• W2022222793 cites W2012949587 @default.
• W2022222793 cites W2014023055 @default.
• W2022222793 cites W2020736186 @default.
• W2022222793 cites W2025582056 @default.
• W2022222793 cites W2026085570 @default.
• W2022222793 cites W2030808052 @default.
• W2022222793 cites W2037468156 @default.
• W2022222793 cites W2039418825 @default.
• W2022222793 cites W2040626078 @default.
• W2022222793 cites W2043151905 @default.
• W2022222793 cites W2046375396 @default.
• W2022222793 cites W2076357842 @default.
• W2022222793 cites W2077409457 @default.
• W2022222793 cites W2102732416 @default.
• W2022222793 cites W2119305815 @default.
• W2022222793 cites W2128931040 @default.
• W2022222793 cites W2137427257 @default.
• W2022222793 cites W2137889830 @default.
• W2022222793 cites W2160047008 @default.
• W2022222793 cites W2420895977 @default.
• W2022222793 doi "https://doi.org/10.1016/j.bmcl.2011.02.115" @default.
• W2022222793 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3070790" @default.
• W2022222793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21421315" @default.
• W2022222793 hasPublicationYear "2011" @default.
• W2022222793 type Work @default.
• W2022222793 sameAs 2022222793 @default.
• W2022222793 citedByCount "10" @default.
• W2022222793 countsByYear W20222227932013 @default.
• W2022222793 countsByYear W20222227932014 @default.
• W2022222793 countsByYear W20222227932015 @default.
• W2022222793 countsByYear W20222227932016 @default.
• W2022222793 countsByYear W20222227932017 @default.
• W2022222793 countsByYear W20222227932018 @default.
• W2022222793 countsByYear W20222227932019 @default.
• W2022222793 crossrefType "journal-article" @default.
• W2022222793 hasAuthorship W2022222793A5010846884 @default.
• W2022222793 hasAuthorship W2022222793A5024312004 @default.
• W2022222793 hasAuthorship W2022222793A5034253457 @default.
• W2022222793 hasAuthorship W2022222793A5035202093 @default.
• W2022222793 hasAuthorship W2022222793A5073379520 @default.
• W2022222793 hasAuthorship W2022222793A5077133720 @default.
• W2022222793 hasAuthorship W2022222793A5091485962 @default.
• W2022222793 hasBestOaLocation W20222227932 @default.
• W2022222793 hasConcept C181199279 @default.
• W2022222793 hasConcept C185592680 @default.
• W2022222793 hasConcept C2776714187 @default.
• W2022222793 hasConcept C2777010668 @default.
• W2022222793 hasConcept C2777367657 @default.
• W2022222793 hasConcept C2779186577 @default.
• W2022222793 hasConcept C2780358027 @default.
• W2022222793 hasConcept C2994342964 @default.
• W2022222793 hasConcept C55493867 @default.
• W2022222793 hasConcept C71924100 @default.
• W2022222793 hasConcept C86803240 @default.
• W2022222793 hasConcept C89423630 @default.
• W2022222793 hasConcept C98274493 @default.
• W2022222793 hasConceptScore W2022222793C181199279 @default.
• W2022222793 hasConceptScore W2022222793C185592680 @default.
• W2022222793 hasConceptScore W2022222793C2776714187 @default.
• W2022222793 hasConceptScore W2022222793C2777010668 @default.
• W2022222793 hasConceptScore W2022222793C2777367657 @default.
• W2022222793 hasConceptScore W2022222793C2779186577 @default.
• W2022222793 hasConceptScore W2022222793C2780358027 @default.
• W2022222793 hasConceptScore W2022222793C2994342964 @default.
• W2022222793 hasConceptScore W2022222793C55493867 @default.
• W2022222793 hasConceptScore W2022222793C71924100 @default.
• W2022222793 hasConceptScore W2022222793C86803240 @default.
• W2022222793 hasConceptScore W2022222793C89423630 @default.
• W2022222793 hasConceptScore W2022222793C98274493 @default.
• W2022222793 hasIssue "8" @default.
• W2022222793 hasLocation W20222227931 @default.
• W2022222793 hasLocation W20222227932 @default.
• W2022222793 hasLocation W20222227933 @default.
• W2022222793 hasLocation W20222227934 @default.
• W2022222793 hasOpenAccess W2022222793 @default.
• W2022222793 hasPrimaryLocation W20222227931 @default.
• W2022222793 hasRelatedWork W113230002 @default.
• W2022222793 hasRelatedWork W2108780469 @default.
• W2022222793 hasRelatedWork W2161466677 @default.
• W2022222793 hasRelatedWork W2393693149 @default.
• W2022222793 hasRelatedWork W2795943227 @default.

• next