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- W2022225726 abstract "The kinetics of degradation of neutral and acidic molecules which form acidic products in unbuffered solutions has been considered. The validity of the analytic solutions for autocatalytic cases involving specific acid catalysis in competition with specific base catalysis or spontaneous degradation has been verified through analog simulation of the reactions. Since the time required for 10 per cent degradation of a drug is of pharmaceutical interest, the effect on this parameter of variation in initial concentration of drug, rate constants, and dissociation constants of reactants and products was investigated. The equations presented may be applied to the estimation of drug stability under the conditions described, if the relevant kinetic parameters are known. The kinetics of degradation of neutral and acidic molecules which form acidic products in unbuffered solutions has been considered. The validity of the analytic solutions for autocatalytic cases involving specific acid catalysis in competition with specific base catalysis or spontaneous degradation has been verified through analog simulation of the reactions. Since the time required for 10 per cent degradation of a drug is of pharmaceutical interest, the effect on this parameter of variation in initial concentration of drug, rate constants, and dissociation constants of reactants and products was investigated. The equations presented may be applied to the estimation of drug stability under the conditions described, if the relevant kinetic parameters are known." @default.
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- W2022225726 date "1964-04-01" @default.
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- W2022225726 title "Kinetics of Hydrolytic Degradation in Unbuffered Solutions" @default.
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- W2022225726 doi "https://doi.org/10.1002/jps.2600530414" @default.
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