FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022226324> ?p ?o ?g. }

• W2022226324 endingPage "3426" @default.
• W2022226324 startingPage "3410" @default.
• W2022226324 abstract "Human G protein-coupled receptor 30 (GPR30) mediates estradiol-17beta (E2) activation of adenylyl cyclase in breast cancer cells and displays E2 binding typical of membrane estrogen receptors (mERs). We identified a mER in Atlantic croaker ovaries with characteristics similar to those of human GPR30. To confirm the proposed role of GPR30 as a mER in this distantly related vertebrate group, we cloned GPR30 from croaker ovaries and examined its distribution, steroid binding, and signaling characteristics. Western blot analysis showed the GPR30 protein (approximately 40 kDa) is expressed on the plasma membranes of croaker oocytes and HEK293 cells stably transfected with GPR30 cDNA. Plasma membranes prepared from croaker GPR30-transfected cells displayed high-affinity, limited-capacity, and displaceable binding specific for estrogens, characteristic of mERs. Consistent with previous findings with human GPR30, estrogen treatment of plasma membranes from both croaker ovaries and GPR30-transfected cells caused activation of a stimulatory G protein (Gs) resulting in increased cAMP production. Treatment with E2 as well as G-1, a specific GPR30 ligand, significantly reduced both spontaneous and progestin-induced maturation of both croaker and zebrafish oocytes in vitro, suggesting a possible involvement of GPR30 in maintaining oocyte meiotic arrest in these species. Injection of antisense oligonucleotides to GPR30 into zebrafish oocytes blocked the inhibitory effects of estrogen on oocyte maturation, confirming a role for GPR30 in the control of meiotic arrest. These findings further support our previous suggestion that GPR30 is a vertebrate mER. In addition, the results suggest GRP30 may play a critical role in regulating reentry into the meiotic cell cycle in fish oocytes." @default.
• W2022226324 created "2016-06-24" @default.
• W2022226324 creator A5018854741 @default.
• W2022226324 creator A5019628949 @default.
• W2022226324 creator A5029049466 @default.
• W2022226324 date "2008-04-17" @default.
• W2022226324 modified "2023-10-14" @default.
• W2022226324 title "Estrogen Signaling Characteristics of Atlantic Croaker G Protein-Coupled Receptor 30 (GPR30) and Evidence It Is Involved in Maintenance of Oocyte Meiotic Arrest" @default.
• W2022226324 cites W1958808161 @default.
• W2022226324 cites W1964638513 @default.
• W2022226324 cites W1967479320 @default.
• W2022226324 cites W1967810257 @default.
• W2022226324 cites W1967990741 @default.
• W2022226324 cites W1972086601 @default.
• W2022226324 cites W1976217984 @default.
• W2022226324 cites W1981467972 @default.
• W2022226324 cites W1981746913 @default.
• W2022226324 cites W1982378926 @default.
• W2022226324 cites W1984638038 @default.
• W2022226324 cites W1985941840 @default.
• W2022226324 cites W1990281442 @default.
• W2022226324 cites W1993423315 @default.
• W2022226324 cites W2007974463 @default.
• W2022226324 cites W2027501985 @default.
• W2022226324 cites W2035685439 @default.
• W2022226324 cites W2036711488 @default.
• W2022226324 cites W2037790468 @default.
• W2022226324 cites W2042408728 @default.
• W2022226324 cites W2049116118 @default.
• W2022226324 cites W2049783385 @default.
• W2022226324 cites W2054519659 @default.
• W2022226324 cites W2059794064 @default.
• W2022226324 cites W2063771267 @default.
• W2022226324 cites W2066546360 @default.
• W2022226324 cites W2072217210 @default.
• W2022226324 cites W2072338652 @default.
• W2022226324 cites W2078322680 @default.
• W2022226324 cites W2091196189 @default.
• W2022226324 cites W2092184448 @default.
• W2022226324 cites W2095336921 @default.
• W2022226324 cites W2098963564 @default.
• W2022226324 cites W2101467600 @default.
• W2022226324 cites W2114313654 @default.
• W2022226324 cites W2119937601 @default.
• W2022226324 cites W2120222884 @default.
• W2022226324 cites W2122015809 @default.
• W2022226324 cites W2128288344 @default.
• W2022226324 cites W2128721915 @default.
• W2022226324 cites W2132286468 @default.
• W2022226324 cites W2137272726 @default.
• W2022226324 cites W2137681063 @default.
• W2022226324 cites W2137832158 @default.
• W2022226324 cites W2139945041 @default.
• W2022226324 cites W2149713530 @default.
• W2022226324 cites W2152824333 @default.
• W2022226324 cites W2153918480 @default.
• W2022226324 cites W2158855816 @default.
• W2022226324 cites W2160270310 @default.
• W2022226324 cites W2163174772 @default.
• W2022226324 cites W2163865126 @default.
• W2022226324 cites W4243316564 @default.
• W2022226324 cites W4382238370 @default.
• W2022226324 doi "https://doi.org/10.1210/en.2007-1663" @default.
• W2022226324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2453078" @default.
• W2022226324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18420744" @default.
• W2022226324 hasPublicationYear "2008" @default.
• W2022226324 type Work @default.
• W2022226324 sameAs 2022226324 @default.
• W2022226324 citedByCount "120" @default.
• W2022226324 countsByYear W20222263242012 @default.
• W2022226324 countsByYear W20222263242013 @default.
• W2022226324 countsByYear W20222263242014 @default.
• W2022226324 countsByYear W20222263242015 @default.
• W2022226324 countsByYear W20222263242016 @default.
• W2022226324 countsByYear W20222263242017 @default.
• W2022226324 countsByYear W20222263242018 @default.
• W2022226324 countsByYear W20222263242019 @default.
• W2022226324 countsByYear W20222263242020 @default.
• W2022226324 countsByYear W20222263242021 @default.
• W2022226324 countsByYear W20222263242022 @default.
• W2022226324 countsByYear W20222263242023 @default.
• W2022226324 crossrefType "journal-article" @default.
• W2022226324 hasAuthorship W2022226324A5018854741 @default.
• W2022226324 hasAuthorship W2022226324A5019628949 @default.
• W2022226324 hasAuthorship W2022226324A5029049466 @default.
• W2022226324 hasBestOaLocation W20222263242 @default.
• W2022226324 hasConcept C121608353 @default.
• W2022226324 hasConcept C126322002 @default.
• W2022226324 hasConcept C134018914 @default.
• W2022226324 hasConcept C166471694 @default.
• W2022226324 hasConcept C2777164284 @default.
• W2022226324 hasConcept C530470458 @default.
• W2022226324 hasConcept C71924100 @default.
• W2022226324 hasConcept C84606932 @default.
• W2022226324 hasConcept C86803240 @default.
• W2022226324 hasConcept C95444343 @default.
• W2022226324 hasConceptScore W2022226324C121608353 @default.
• W2022226324 hasConceptScore W2022226324C126322002 @default.

• next